Results 51 to 60 of about 1,005 (158)
Pharmaceutics, 2019 This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling.
Tae Hwan Kim +4 more
doaj +1 more source
Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction
WIREs Computational Molecular Science, Volume 16, Issue 1, January/February 2026.This figure summarizes the different methods in integrative predictive toxicology reviewed in this work, ranging from exploration of molecular mechanisms to in silico pharmacokinetic modeling and construction of adverse outcome pathway (AOP) networks based on key events (KEs) and key event relationships (KERs). Further integration with multi‐omics data
Eleonora Gianquinto +6 more
wiley +1 more source
Pharmaceutics, 2020 The aim of the present study was to bring additional evidence regarding a biopredictive dissolution medium containing 1% sodium lauryl sulphate (SLS) to predict the in vivo behavior of carbamazepine (CBZ) products.
Marival Bermejo +5 more
doaj +1 more source
Journal of Nanotechnology, Volume 2026, Issue 1, 2026.Rapid industrialization and urbanization have intensified environmental pollution, including persistent organic contaminants and toxic metals that threaten ecosystems and human health. Green‐synthesized titanium dioxide (TiO2) nanoparticles (NPs) are gaining attention for their lower‐hazard reagents, reduced energy inputs, and competitive performance ...
Tusha Yadav +7 more
wiley +1 more source
Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1329-1339, December 2025.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source
Pharmaceutics, 2019 In this study a novel type of in vitro−in vivo correlation (IVIVC) is proposed: The correlation of the in vitro parent drug dissolution data with the in vivo pharmacokinetic data of drug’s metabolite after the oral administration of the ...
Constantin Mircioiu +4 more
doaj +1 more source
Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution
Pharmaceutics, 2023 Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness.
Magdalena Markowicz-Piasecka +6 more
doaj +1 more source
An in vitro-in vivo correlation study of modified release formulations of Venlafaxine.HCl
Revista de Ciências Farmacêuticas Básica e Aplicada, 2014 A single dose, randomized, complete and four treatment cross over study was conducted in healthy human subjects for IVIVC of venlafaxine.HCl. Plasma concentrations were estimated by a simple, rapid, sensitive and validated LCMS method.
J.R. Aravindaraj +2 more
doaj +2 more sources
Applied Sciences, 2020 The increasing emergence of drug-resistant tuberculosis requires new effective and safe drug regimens. However, drug discovery and development are challenging, lengthy and costly.
Rob C. van Wijk +3 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1499-1511, December 2025.Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe +4 more
wiley +1 more source