Results 21 to 30 of about 1,005 (158)
Pharmaceutics, 2020 This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro−in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution.
Dong-Seok Lee +4 more
doaj +1 more source
Translational Physiologically Based Pharmacokinetic Modeling to Predict Human Pulmonary Kinetics After Lung Delivery. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Predicting human lung exposure with reasonable certainty of orally inhaled drugs based on preclinical studies remains a challenge for drug development. We have developed a comprehensive physiologically based pharmacokinetic (PBPK) framework tailored for the pulmonary pharmacokinetic (PK) behavior in both humans and rats, aiming to bridge the ...
Wen H +3 more
europepmc +2 more sources
Physiologically-Based IVIVC of Azithromycin [PDF]
American Journal of Pharmacological Sciences, 2014 Aim of the study is to establish physiologically-based in vitro in vivo correlation (IVIVC) of azithromycin, a biopharmaceutics classification system (BCS) class II drug (high permeability/ low solubility). In vitro dissolution was done using USP apparatus II in pH 6 phosphate buffer at 50 rpm.
Nasir M. Idkaidek +3 more
openaire +1 more source
Pharmaceutics, 2021 Health authorities carefully evaluate any change in the batch manufacturing process of a drug before and after regulatory approval. In the absence of an adequate in vitro–in vivo correlation (Level A IVIVC), an in vivo bioequivalence (BE) study is ...
Elena M. Tosca +7 more
doaj +1 more source
Molecules, 2023 As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs (BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the gastrointestinal tract, leading to less qualified in vitro–in vivo correlation (
Yanxiong Gan +9 more
doaj +1 more source
IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening
Pharmaceutics, 2019 Since most preclinical drug permeability assays across the blood-brain barrier (BBB) are still evaluated in rodents, we compared an in vitro mouse primary endothelial cell model to the mouse b.End3 and the acellular parallel artificial membrane ...
Ina Puscas +7 more
doaj +1 more source
Candesartan Cilexetil In Vitro–In Vivo Correlation: Predictive Dissolution as a Development Tool
Pharmaceutics, 2020 The main objective of this investigation was to develop an in vitro–in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development tool.
Andrés Figueroa-Campos +7 more
doaj +1 more source
Pharmaceutics, 2021 The present work evaluates the food effect on the absorption of rivaroxaban (Riva), a BCS II drug, from the orally administered commercial immediate-release tablet (Xarelto IR) using physiologically based pharmacokinetic (PBPK) and conventional in vitro ...
Varun Kushwah +5 more
doaj +1 more source
DISSOLUTION TEST FOR MIANSERIN HYDROCHLORIDE IN TABLETS
Drug Analytical Research, 2019 A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method.
Letícia Lenz Sfair +3 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2021 Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo correlations (IVIVCs) for LBFs is quite challenging, owing to a complex in ...
Yanping Huang +5 more
doaj +1 more source