Results 71 to 80 of about 136,291 (302)

DISSOLUTION MEDIA USED IN DEVELOPMENT AND QUALITY CONTROL OF DRUGS

Разработка и регистрация лекарственных средств, 2019
The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown.
O. V. Druzhininskaya, I. E. Smekhova
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Formulation and In Vitro Evaluation of Matrix Tablets Containing Ketoprofen–Beta Cyclodextrin Complex for Enhanced Rheumatoid Arthritis Therapy: Experimental and Computational Insights

Pharmaceutics
Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment.
Monica Stamate Cretan, Lacramioara Ochiuz, Vlad Ghizdovat, Monica Molcalut, Maricel Agop, Carmen Anatolia Gafițanu, Alexandra Barsan (Bujor), Mousa Sha’at, Ciprian Stamate   +8 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

A review of the antecedents of union dissolution [PDF]

The question of what factors contribute to the stability of coresidential partnerships has attracted the attention of many social scientists. This study summarizes recent research on the determinants of union dissolution within a set of substantive ...
Torkild Lyngstad, Marika Jalovaara
core  

A COMPARATIVE STUDY OF DRUG RELEASE FROM POLYCOMPLEX MATRICES IN STANDARD AND BIORELEVANT MEDIA USING USP III AND USP IV APPARATUS

Разработка и регистрация лекарственных средств, 2019
The results of Indomethacin release from the oral drug delivery systems based on interpolymer complexes with Eudragit® copolymers are presented.
A. V. Sitenkova (Bukhovets), N. Fotaki, R. I. Moustafine   +2 more
doaj  

Application of bovine progesterone intravaginal controlled-release formulation for estrus synchronization treatment in goats

The Journal of Reproduction and Development
Progesterone (P4)-impregnated controlled internal drug-releasing device for goats and sheep (CIDR-G) is used in the estrus synchronization protocol; however, it is not commercially available in Japan. In this study, we investigated whether a modification
Kotaro SAITO, Tomomi TANAKA, Natsumi ENDO   +2 more
doaj   +1 more source

Development and Laboratory Test of All-Metal Bridge Plug for Ultra-High Temperature Environments

Shiyou jixie, 2023
Soluble bridge plugs are deficient for low compressive strength,slow degradation rate,and inapplicability to ultra-high temperature environment.For these problems,an innovative design of all-metal bridge plug for ultra-high temperature environments was ...
Cheng Yuxiong, Wu Guang'ai, Wu Shiyun, Wang Li, Jiang Xu, Gu Peng   +5 more
doaj  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

THE FEATURES OF THE PREDICTIVE DISSOLUTION TESTING (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Dissolution test plays an important role at different levels of the development and manufacturing drugs as one of the major quality control tools and an integral part of In vitro tests in the study of drug release from the developed dosage forms. Article
R. I. Moustafine, A. V. Sitenkova (Bukhovets), N. Fotaki   +2 more
doaj