Results 111 to 120 of about 3,272,786 (313)
Editorial ~ Open Access in Action!
International Review of Research in Open and Distributed Learning, 2006 Mid 2006 finds the academic research community engaged in an ideological and fiscal war related to Open Access publishing. Open Access requires that the full text of publications be made available at no cost to anyone on the open Internet.
Terry Anderson, Canada Research Chair in Distance Education
doaj
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
On distance preserving and sequentially distance preserving graphs
The Art of Discrete and Applied MathematicsA graph $H$ is an \emph{isometric} subgraph of $G$ if $d_H(u,v)= d_G(u,v)$, for every pair~$u,v\in V(H)$. A graph is \emph{distance preserving} if it has an isometric subgraph of every possible order. A graph is \emph{sequentially distance preserving} if its vertices can be ordered such that deleting the first $i$ vertices results in an isometric ...
Jason P. Smith, Emad Zahedi
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Journal of Open, Flexible and Distance Learning, 2012 Column about conferences events and new publications in distance learning.
Glenise Dreaver, Terry Hearn
doaj +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source