Results 21 to 30 of about 457,134 (297)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
SolarPACES Conference ProceedingsThis study focuses on performing a parametric analysis of the non-compact concentrated solar power (CSP)-photovoltaic (PV) hybrid plant combined with an electric heater (EH) and a Supercritical Rankine Cycle as well as a multi-objective optimization of ...
Rubén Barbero +4 more
doaj +1 more source
Coping with burnout: analysis of linear, non-linear and interaction relationships
Anales de Psicologia, 2017 This study analyzes the relationship between action-focused coping, emotion-focused coping and burnout dimensions (emotional exhaustion, cynicism and personal accomplishment) by comparing linear, non-linear and interaction models using quadratic ...
José A. García-Arroyo, Amparo Osca
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
“Spray Technique: Tracing the Sketch Traditions of Limestone Cave in Lenggong, Perak”
SHS Web of Conferences, 2015 Archaeological research provides the widest opportunity for researchers to analyse various aspects and disciplines appropriate to the subject and the object of choice.
Yahaya Fatan Hamamah +3 more
doaj +1 more source
International Journal of Educational Technology in Higher Education, 2020 Higher education institutions are increasingly interested in using adaptive learning as an innovative data-driven approach to teaching. The actual use of adaptive learning in courses remains, however, low.
Victoria Mirata +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Getting the Mix Right Again: An Updated and Theoretical Rationale for Interaction
International Review of Research in Open and Distributed Learning, 2003 No topic raises more contentious debate among educators than the role of interaction as a crucial component of the education process. This debate is fueled by surface problems of definition and vested interests of professional educators, but is more ...
Terry Anderson, Canada Research Chair in Distance Education
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Cogent Education, 2023 The incongruity between academic programmes pursued and the career path among graduates in recent times suggests that career path does not always lead to programme choice and vice versa. Different occupations/professions not directly found in the area of
Moses Segbenya +3 more
doaj +1 more source