Results 31 to 40 of about 457,134 (297)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
International Review of Research in Open and Distributed Learning, 2002 We know that significant organizational change must have roots both at the top of an organization and “in the trenches” amongst those who must implement the change.
Terry Anderson, Canada Research Chair in Distance Education
doaj
Learning Analytics in Open, Distance, and Digital Education (ODDE) [PDF]
, 2023 Paul Prinsloo
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
International Review of Research in Open and Distributed Learning, 2004 With significant male trepidation, I want to share a birth story with IRRODL readers. This month, after a seemingly endless gestation, the Canadian Institute for Distance Education Research (CIDER) was born. Like most births, this new presence began with
Terry Anderson, Canada Research Chair in Distance Education
doaj
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Editorial ~ Open Access in Action!
International Review of Research in Open and Distributed Learning, 2006 Mid 2006 finds the academic research community engaged in an ideological and fiscal war related to Open Access publishing. Open Access requires that the full text of publications be made available at no cost to anyone on the open Internet.
Terry Anderson, Canada Research Chair in Distance Education
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Using Web-Based, Group Communication Systems to Support Case Study Learning at a Distance
International Review of Research in Open and Distributed Learning, 2002 This study explored the capacity of Web-based, group communication systems to support case-based teaching and learning. Eleven graduate students studying at a distance were divided into three groups to collaborate on a case study using either a ...
Liam Rourke +1 more
doaj