Results 31 to 40 of about 442,809 (277)

Getting the Mix Right Again: An Updated and Theoretical Rationale for Interaction

International Review of Research in Open and Distributed Learning, 2003
No topic raises more contentious debate among educators than the role of interaction as a crucial component of the education process. This debate is fueled by surface problems of definition and vested interests of professional educators, but is more ...
Terry Anderson, Canada Research Chair in Distance Education
doaj  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Book Review ~ Delivering Digitally: Managing the transition to the knowledge media. Edited by A. Inglis, P. Ling, and V. Joosten

International Review of Research in Open and Distributed Learning, 2002
We know that significant organizational change must have roots both at the top of an organization and “in the trenches” amongst those who must implement the change.
Terry Anderson, Canada Research Chair in Distance Education
doaj  

Factors Affecting the Participation of the Deaf and Hard of Hearing in e-Learning and Their Satisfaction: A Quantitative Study

International Review of Research in Open and Distributed Learning, 2017
Today the digital divide is measured not so much by access to the internet but by people's ability to interact in cyberspace, which calls for specific digital communication skills.
Emilio Ferreiro Lago, Sara Osuna Acedo
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Editorial ~ CIDER is Born

International Review of Research in Open and Distributed Learning, 2004
With significant male trepidation, I want to share a birth story with IRRODL readers. This month, after a seemingly endless gestation, the Canadian Institute for Distance Education Research (CIDER) was born. Like most births, this new presence began with
Terry Anderson, Canada Research Chair in Distance Education
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Editorial ~ Open Access in Action!

International Review of Research in Open and Distributed Learning, 2006
Mid 2006 finds the academic research community engaged in an ideological and fiscal war related to Open Access publishing. Open Access requires that the full text of publications be made available at no cost to anyone on the open Internet.
Terry Anderson, Canada Research Chair in Distance Education
doaj  

Professional task-based curriculum development for distance education practitioners at master’s level: A design-based research

International Review of Research in Open and Distributed Learning, 2015
Curriculum development for distance education (DE) practitioners is more and more focusing on practical requirements and competence development. Delphi and DACUM methods have been used at some universities.
Xiaoying Feng, Guangxin Lu, Zhihong Yao
doaj   +1 more source