Results 51 to 60 of about 442,809 (277)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Romantic Attachment and Cognitive-Emotional Regulation in Psychological Maladjustment
Clínica y Salud. Investigación Empírica en PsicologíaRomantic Attachment and Psychological Maladjustment: The study reveals that romantic attachment is a significant predictor of psychological maladjustment and depression.
Alicia Mena +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The use of WCAG and automatic tools by computer science students: a case study evaluating MOOC accessibility [PDF]
Journal of Universal Computer ScienceWeb Content Accessibility Guidelines (WCAG) have been the de facto standard for Web accessibility evaluation for more than two decades and therefore have been introduced into legislation and university curriculum in Computer Science.
Francisco Iniesto, Covadonga Rodrigo
doaj +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Scale-Up Considerations of the Sundial Rotating Fresnel Solar Collector
SolarPACES Conference ProceedingsIn the frame of the ASTEP project two prototypes of the Sundial collector, together with a Phase Change Material Thermal Energy Storage, will be tested integrated with the industrial processes of two sites.
Mercedes Ibarra +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Exploring students’ experiences with authentic assessment in an online learning context
International Journal of Educational Management and Development StudiesAuthentic assessment brings a new dimension to assessment where learning and assessment are linked to genuine workplace environments. In this assessment, students apply knowledge and skills to solve real and felt workplace problems.
Cosmas Maphosa +2 more
doaj +1 more source
SHS Web of Conferences, 2014 Lembah Lenggong is a place well known amongst locals as an archaeological site; the valley has been attested as a World Heritage Site. There is an overwhelming variety of plant species that are uniquely used in their cultural and traditional cuisines ...
Abd Aziz Siti Hajar +2 more
doaj +1 more source