Results 71 to 80 of about 442,809 (277)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

Modelling the antecedents of students’ attitudes toward examination malpractice and intentions in distance education

open access: yesDiscover Education
Examination malpractice in distance education is a growing concern as it is gaining roots in the academic work of students in recent years. The prevalence of academic malpractice is difficult to measure, as it often goes unreported or undetected, but ...
Brandford Bervell   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Entrepreneurship as a Catalyst for Rural Tourism Development

open access: yesSHS Web of Conferences, 2014
The tourism industry is seen as capable of being an agent of change in the landscape of economic, social and environment of a tourist destination. Tourism activity has also generated employment and entrepreneurship opportunities to the local community as
Md Sharif Norhafiza, Tuan Lonik Ku Azam
doaj   +1 more source

Analysis of risks in a Learning Management System: A case study in the Spanish National University of Distance Education (UNED)

open access: yesJournal of New Approaches in Educational Research, 2015
This article presents a research that examines the university students' risk perception when using a Learning Management System called “aLF” and implemented by the Spanish National University of Distance Education (UNED) for the development of its ...
Esteban Vázquez Cano   +1 more
doaj   +1 more source

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