Results 131 to 140 of about 5,019,889 (353)

Young stellar distance indicators and the extragalactic distance scale

open access: yes, 2023
Invited review at 2022 RR Lyrae and Cepheids conference on La Palma.
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Large-Scale Bulk Motions Complicate the Hubble Diagram

open access: yes, 2006
We investigate the extent to which correlated distortions of the luminosity distance-redshift relation due to large-scale bulk flows limit the precision with which cosmological parameters can be measured.
Asantha Cooray   +6 more
core   +1 more source

Relationships between some distance-based topological indices

open access: yesFilomat, 2018
The Harary index (HI), the average distance (AD), the Wiener polarity index (WPI) and the connective eccentricity index (CEI) are distance-based graph invariants, some of which found applications in chemistry. We investigate the relationship between HI, AD, and CEI, and between WPI, AD, and CEI.
Hua H.   +3 more
openaire   +4 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Gamma-ray bursts as X-ray depth-gauges of the Universe

open access: yes, 2003
We discuss the X-ray flux of gamma-ray burst afterglows at redshifts in the range 3-30, including the effects of the intergalactic He II absorption. We point out that strong X-ray lines may form locally in burst afterglows starting minutes after the ...
Meszaros, P., Rees, M. J.
core   +1 more source

Type Ia Supernovae as Extragalactic Distance Indicators [PDF]

open access: green, 1996
David Branch, P. Nugent, Adam Fisher
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

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