Results 121 to 130 of about 236,736 (305)

The socio-economic impacts of long distance commuting (LDC) on source communities [PDF]

, 2013
Background: The current mining boom has brought considerable wealth throughout Australia, but the benefits are not distributed evenly. The majority of Australian mining activities are in remote locations where demand for labour usually exceeds local ...
Hoath, Aileen, Aileen Hoath, McKenzie, Fiona Haslam, Fiona Haslam-McKenzie   +3 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Chicago–Carnegie Hubble Program: A Multiwavelength Search for the Effects of Metallicity on the Cepheid Distance Scale. I. Empirical Evidence

The Astrophysical Journal
Understanding the effects of metallicity on the multiwavelength properties of Cepheids is of continuing importance for their effective use as extragalactic distance indicators and an accurate measure of the Hubble constant, H _0 .
Barry F. Madore, Wendy L. Freedman
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The Cepheid Distance Scale: A Novel Method for Obtaining Mean Magnitudes from Single-epoch Observations

The Astronomical Journal
We present a novel technique for mapping single-phase observations of Cepheids in any given band into their time-averaged values, using strong priors on the known interrelations of the multiwavelength widths of Cepheid period–luminosity (PL) relations ...
Barry F. Madore, Wendy L. Freedman, Kayla Owens   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Productivity and Subsidies in European Union Countries: An Analysis for Dairy Farms Using Input Distance Frontiers [PDF]

The major objective of this paper is to examine the association between agricultural subsidies and farm efficiency using data from the European Farm Accountancy Data Network (FADN) for operations specializing on dairy.
Bravo-Ureta, Boris E., Moreira, Victor H., Latruffe, Laure, Dupraz, Pierre, Desjeux, Yann   +4 more
core   +1 more source

The Milky Way as Seen by Classical Cepheids. I. Distances Based on Mid-infrared Photometry

The Astrophysical Journal Supplement Series
Classical Cepheids are the archetype of the standard candle, thanks to the period–luminosity relation, which allows us to measure their intrinsic brightness.
Dorota M. Skowron, Ronald Drimmel, Shourya Khanna, Alessandro Spagna, Eloisa Poggio, Pau Ramos   +5 more
doaj   +1 more source