Results 121 to 130 of about 4,651,873 (337)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
On the Geography of Trade: Distance is Alive and Well [PDF]
It has been widely argued that, with the decline in trade costs, the importance of distance has declined over time. On the other hand, most gravity models find that the importance of distance has increased over time.
Céline CARRERE, Maurice SCHIFF
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Variables as stellar tracers and distance indicators [PDF]
, 2015 The importance of pulsating stars as stellar population tracers and primary distance indicators is briefly reviewed. In particular, we discuss several approaches based on the comparison between the predictions of nonlinear convective pulsation models and
MARCONI, Marcella
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Radio Supernovae as Distance Indicators
The Astrophysical Journal, 1998 Long-term monitoring of the radio emission from supernovae with the Very Large Array (VLA) shows that the radio ``light curves'' evolve in a systematic fashion with a distinct peak flux density (and thus, in combination with a distance, a peak spectral luminosity) at each frequency and a well-defined time from explosion to that peak. Studying these two
Weiler, K. W. +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Infeasibility and Directional Distance Functions with Application to the Determinateness of the Luenberger Productivity Indicator [PDF]
The purpose of this contribution is to highlight an underexplored property of the directional distance function, a recently introduced generalization of the Shephard distance function.
Kristiaan Kerstens, Walter Briec
core
Toward an Internally Consistent Astronomical Distance Scale
, 2017 Accurate astronomical distance determination is crucial for all fields in astrophysics, from Galactic to cosmological scales. Despite, or perhaps because of, significant efforts to determine accurate distances, using a wide range of methods, tracers, and
Monelli, Matteo +17 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source