Results 131 to 140 of about 1,090,152 (292)

Toward Precision Cosmology with Improved Planetary Nebula Luminosity Function Distances Using VLT-MUSE. II. A Test Sample from Archival Data

The Astrophysical Journal Supplement Series
Thanks to the MUSE integral field spectrograph on board the Very Large Telescope (VLT), extragalactic distance measurements with the [O iii ] λ 5007 planetary nebula luminosity function (PNLF) are now possible out to ∼40 Mpc. Here we analyze the VLT/MUSE
George H. Jacoby, Robin Ciardullo, Martin M. Roth, Magda Arnaboldi, Peter M. Weilbacher   +4 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Examining regional disparities in maternal and child health in Bangladesh using cluster analysis of MICS 2019 data

Scientific Reports
Child and maternal health are crucial indicators of the health status of a country’s population. However, there is a regional variability among health indicators and the availability of health services.
Moinur Rahman, Md. Fajla Rabby, Md. Mojammel Haque Sakib, Md. Moyazzem Hossain   +3 more
doaj   +1 more source

On the Nonclassicality Distance Indicator of Qudits

Physics of Particles and Nuclei
We consider the nonclassicality distance indicator of a state in finite-dimensional quantum systems which is evaluating a state nonclassicality by its remoteness from the set of "classical states". The latter are identified with those states whose Wigner function is non-negative. The corresponding Wigner function's positivity polytope in the simplex of
Khvedelidze, Arsen, Torosyan, Astghik
openaire   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Cepheids as Distance Indicators: Some Current Problems

Odessa Astronomical Publications, 2001
A general review is given of the calibration of the Cepheid distance scale, with particular reference to its use in the determination of H0. Emphasis is placed on the advantage of using a galactic calibration of the Cepheid scale, rather than relying on an adopted distance to the LMC. It is then possible to use LMC data to test for possible metallicity
openaire   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source