Results 151 to 160 of about 5,019,889 (353)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Cepheid Distance Scale: A Novel Method for Obtaining Mean Magnitudes from Single-epoch Observations

The Astronomical Journal
We present a novel technique for mapping single-phase observations of Cepheids in any given band into their time-averaged values, using strong priors on the known interrelations of the multiwavelength widths of Cepheid period–luminosity (PL) relations ...
Barry F. Madore, Wendy L. Freedman, Kayla Owens   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Milky Way as Seen by Classical Cepheids. I. Distances Based on Mid-infrared Photometry

The Astrophysical Journal Supplement Series
Classical Cepheids are the archetype of the standard candle, thanks to the period–luminosity relation, which allows us to measure their intrinsic brightness.
Dorota M. Skowron, Ronald Drimmel, Shourya Khanna, Alessandro Spagna, Eloisa Poggio, Pau Ramos   +5 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Toward Precision Cosmology with Improved Planetary Nebula Luminosity Function Distances Using VLT-MUSE. II. A Test Sample from Archival Data

The Astrophysical Journal Supplement Series
Thanks to the MUSE integral field spectrograph on board the Very Large Telescope (VLT), extragalactic distance measurements with the [O iii ] λ 5007 planetary nebula luminosity function (PNLF) are now possible out to ∼40 Mpc. Here we analyze the VLT/MUSE
George H. Jacoby, Robin Ciardullo, Martin M. Roth, Magda Arnaboldi, Peter M. Weilbacher   +4 more
doaj   +1 more source

Spatial pattern of Manna Oak trees (Quercus brantii Lindl.) in Bayangan forests of Kermanshah [PDF]

تحقیقات جنگل و صنوبر ایران, 2010
In order to have a better recognition of plant communities, studying the spatial pattern of them is necessary to understand many of the issues in forest ecology and management.
Amir Safari, Naghi Shabanian, Reza Hoseyn Heidari, Seyyed Yoosof Erfanifard, Morteza Pourreza   +4 more
doaj  

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source