Results 71 to 80 of about 2,194,803 (325)

Distance matrix polynomials of trees

Advances in Mathematics, 1978
AbstractLet G be a finite connected graph. If x and y are vertices of G, one may define a distance function dG on G by letting dG(x, y) be the minimal length of any path between x and y in G (with dG(x, x) = 0). Thus, for example, dG(x, y) = 1 if and only if {x, y} is an edge of G.
Graham, R.L, Lovász, L
openaire   +2 more sources

CRITICAL POINTS OF MATRIX LEAST SQUARE DISTANCE FUNCTIONS [PDF]

Linear Algebra and its Applications, 1992
The authors determine the critical points and the local minimum of the Frobenius distance function \(\| A - X \|^ 2\) on varieties of fixed rank symmetric, skew-symmetric, and rectangular matrices \(X\).
Helmke, Uwe, Shayman, Mark A.
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Preserving privacy of spatial distances using randomized geometric surface calculations

Journal of Spatial Information Science
This paper introduces and evaluates a novel method for privacy-preserving distance computations. The method is based on randomized geometric surface calculations and replaces coordinates with contextual variables representing information about the ...
Jonas Klingwort, Sarah Redlich
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Four-point condition matrices of edge-weighted trees

Special Matrices
Formulas for the determinant of distance matrix DT{D}_{T} of tree TT are known in the unweighted case and in the case when the edges of TT have commuting variable weights. Associated with the four-point condition (4PC) and a tree TT are two matrices, the
Azimi Ali, Jana Rakesh, Nagar Mukesh K., Sivasubramanian Sivaramakrishnan   +3 more
doaj   +1 more source

A distance geometry-based description and validation of protein main-chain conformation

IUCrJ, 2017
Understanding the protein main-chain conformational space forms the basis for the modelling of protein structures and for the validation of models derived from structural biology techniques. Presented here is a novel idea for a three-dimensional distance
Joana Pereira, Victor S. Lamzin
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source