Results 111 to 120 of about 10,408,415 (315)

Direct strain and slope measurement using 3D DSPSI [PDF]

open access: yes, 2013
This communication presents a new implementation of DSPSI. Its main features are 1. an advanced model taking into account the beam divergence, 2. the coupling with a surface shape measurement in order to generalize DSPSI to nonplanar surfaces 3.
Dandach, Wajdi   +2 more
core   +2 more sources

A Study of Metrics of Distance and Correlation Between Ranked Lists for Compositionality Detection

open access: yes, 2017
Compositionality in language refers to how much the meaning of some phrase can be decomposed into the meaning of its constituents and the way these constituents are combined.
Hansen, Niels Dalum, Lioma, Christina
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Phase-coded microwave signal generation based on a single electro-optical modulator and its application in accurate distance measurement.

open access: yesOptics Express, 2015
A novel scheme for photonic generation of a phase-coded microwave signal is proposed and its application in one-dimension distance measurement is demonstrated.
Fangzheng Zhang   +3 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

High-precision Absolute Distance and Vibration Measurement using Frequency Scanned Interferometry

open access: yes, 2004
In this paper, we report high-precision absolute distance and vibration measurements performed with frequency scanned interferometry using a pair of single-mode optical fibers.
Barwood   +9 more
core   +3 more sources

DISTANCE MEASURING DEVICE AND DISTANCE MEASURING METHOD

open access: yes, 2018
A distance measuring device includes a light emission portion for emitting light; a light receiving portion for receiving measurement light that is emitted by the light emission portion and reflected by a measurement object, the light receiving portion comprising a plurality of pixels, each pixel having at least one light receiving portion and ...
Y. Matsui   +4 more
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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