Results 31 to 40 of about 52,381 (247)

Concept of Gene Pool and Distant Hybridization in Vegetable Crops

International Journal of Current Microbiology and Applied Sciences, 2022
Wide crossing or distant hybridization is an effective means of transferring desirable genes into cultivated species. It is more successful in closely related species, but as we move towards tertiary gene pool, it turns out to be very hard to move the quality of interest.
Subhashree Subhasmita, N. Pradeepkumara
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Induction of 2n Male Gamete Formation and Creation of Sexual Polyploidy in Medicinal Dendrobium Based on Distant Hybridization

Guangdong nongye kexue
【Objective】To create sexual polyploid resources of medicinal Dendrobium species via the 2n gamete pathway.【Method】Using D. officinale, D. aphyllum, and D. loddigesii as materials, we systematically observed the development of microspores in D. officinale
Renju LIU, Yingxue LI, Ruizhen ZENG, Zhisheng ZHANG, Li XIE, Qian WEI   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Comparative analysis of intermuscular bones in hybrid of female (megalobrama amblycephala × culter alburnus) × male megalobrama amblycephala and its parents

Reproduction and Breeding
Based on the formation of the hybrid lineage of blunt-snout bream (megalobrama amblycephala, BSB) × topmouth culter (culter alburnus, TC), a new kind of hybrid fish is produced by hybridizing the female diploid F1 hybrid of BSB × TC (short for BT) with ...
Kaikun Luo, Zezhou Zhong, Chengxi Liu, Zhonghua Peng, Binchao Liang, Haipeng Guo, Jing Wang, Wuhui Li, Chang Wu, Fangzhou Hu, Shi Wang, Yude Wang, Shengnan Li, Liang Guo, Zhongyuan Shen   +14 more
doaj   +1 more source

Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream? [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACTEmergence of drug-resistantPlasmodium falciparumstrains has led to a situation of haste in the scientific and pharmaceutical communities. Hence, all their efforts are redirected toward finding alternative chemotherapeutic agents that are capable of combating multidrug-resistant parasite strains.
Drishti, Agarwal, Rinkoo D, Gupta, Satish K, Awasthi   +2 more
openaire   +2 more sources