Results 41 to 50 of about 53,095 (277)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hybridization facilitates evolutionary rescue

, 2014
The resilience of populations to rapid environmental degradation is a major concern for biodiversity conservation. When environments deteriorate to lethal levels, species must evolve to adapt to the new conditions to avoid extinction.
Stelkens, Rike B., Hurst, G., Greig, Duncan, Stelkens, R., Greig, D., Brockhurst, Michael A.; id_orcid, Brockhurst, M., Hurst, Gregory D.D.   +7 more
core   +1 more source

Intergeneric Hybridization of Two Stickleback Species Leads to Introgression of Membrane-Associated Genes and Invasive TE Expansion [PDF]

, 2022
Interspecific hybridization has occurred relatively frequently during the evolution of vertebrates. This process usually abolishes reproductive isolation between the parental species.
Tsygankova, Svetlana, Slobodova, Natalia, Rastorguev, Sergey, Boulygina, Eugenia, Nedoluzhko, Artem, Boulygina, Eugenia S., Sharko, Fedor, Galindo-Villegas, Jorge, Teslyuk, Anton, Tsyganova, Svetlana   +9 more
core   +1 more source

Induction of 2n Male Gamete Formation and Creation of Sexual Polyploidy in Medicinal Dendrobium Based on Distant Hybridization

Guangdong nongye kexue
【Objective】To create sexual polyploid resources of medicinal Dendrobium species via the 2n gamete pathway.【Method】Using D. officinale, D. aphyllum, and D. loddigesii as materials, we systematically observed the development of microspores in D. officinale
Renju LIU, Yingxue LI, Ruizhen ZENG, Zhisheng ZHANG, Li XIE, Qian WEI   +5 more
doaj   +1 more source

lncRNA–DNA hybrids regulate distant genes

EMBO reports, 2020
lncRNAs actively regulate gene expression. They contribute to chromosomal interactions at close or distant genomic regions, which, in turn, regulate transcription [1]. Ariel et al [2] reveal in a recent study a new molecular mechanism of the Arabidopsis lncRNA APOLO.
Aina Maria Mas, Maite Huarte
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Comparative analysis of intermuscular bones in hybrid of female (megalobrama amblycephala × culter alburnus) × male megalobrama amblycephala and its parents

Reproduction and Breeding
Based on the formation of the hybrid lineage of blunt-snout bream (megalobrama amblycephala, BSB) × topmouth culter (culter alburnus, TC), a new kind of hybrid fish is produced by hybridizing the female diploid F1 hybrid of BSB × TC (short for BT) with ...
Kaikun Luo, Zezhou Zhong, Chengxi Liu, Zhonghua Peng, Binchao Liang, Haipeng Guo, Jing Wang, Wuhui Li, Chang Wu, Fangzhou Hu, Shi Wang, Yude Wang, Shengnan Li, Liang Guo, Zhongyuan Shen   +14 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source