Results 51 to 60 of about 112,322 (290)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Unfolding and unzipping of single-stranded DNA by stretching
, 2004 We present a theoretical study of single-stranded DNA under stretching. Within the proposed framework, the effects of basepairing on the mechanical response of the molecule can be studied in combination with an arbitrary underlying model of chain ...
Alexei V. Tkachenko +4 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2010 Metal atoms on graphene, when ionized, can act as a point charge impurity to probe a charge response of graphene with the Dirac cone band structure. To understand the microscopic physics of the metal-atom-induced charge and spin polarization in graphene,
Kim, Gunn +3 more
core +1 more source
A Review of Leonardo Caffo and Azzurra Muzzonigro’s “Costruire Futuri: Migrazioni, città, immaginazioni” [PDF]
, 2018 Modernism has provided a strong case for technoprogressivism, innovation and speculation on future possibilities. However, drastic and often devastating consequences have followed modernism such as global warming and mass biodiversity loss.
Umbrello, Steven
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Conceptualist View in the Metaphysics of Species [PDF]
, 2019 The species concept is one of the central concepts in biological science. Although modern systematics speculates about the existence of a complex hierarchy of nested taxa, biological species are considered particularly important for the active role they ...
De Florio, Ciro, Frigerio, Aldo
core +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Homologies in human and Macasa fuscata chromosomes revealed by in situ suppression hybridization with human chromosome specific DNA libraries [PDF]
, 1992 We established chromosomal homologies between all chromosomes of the human karyotype and that of an old world monkey (Macaca fuscata) by chromosomal in situ suppression (CISS) hybridization with human chromosome specific DNA libraries.
Cremer, Thomas +3 more
core +1 more source
Concept of Gene Pool and Distant Hybridization in Vegetable Crops
International Journal of Current Microbiology and Applied Sciences, 2022 Wide crossing or distant hybridization is an effective means of transferring desirable genes into cultivated species. It is more successful in closely related species, but as we move towards tertiary gene pool, it turns out to be very hard to move the quality of interest.
Subhashree Subhasmita, N. Pradeepkumara
openaire +1 more source