Results 91 to 100 of about 3,102,738 (289)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Application of the equality and non-discrimination principles for migrants workers [PDF]
Civilizar, 2012 The principle of equality and non-discrimination is considered one of the main pillars and inspiring in most international instruments on human rights protection.
María Teresa Palacios Sanabria
doaj
Anachronisme et humour : de l’usage intempestif de l’anachronisme dans la fiction en costumes
Mise au Point, 2017 After defining anachronism as a rhetorical process, this article aims to highlight its humorous effects - particularly untimely in the diegetic universe where one a priori expects the least: historical fiction .
Bernard Papin
doaj +1 more source
What is ‘mental action’? [PDF]
, 2019 There has been a resurgence of interest lately within philosophy of mind and action in the category of mental action. Against this background, the present paper aims to question the very possibility, or at least the theoretical ...
Levy, Yair
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Horizontes Antropológicos, 2010 Le nom de Roger Bastide est généralement associé à la sociologie des religions du Brésil. On peut cependant trouver dans son œuvre un paradigme pertinent pour une analyse anthropologique des styles de vie.
Michel Daccache
doaj +1 more source
Psychosemantic analyticity [PDF]
, 2001 It is widely agreed that the content of a logical concept such as and is constituted by the inferences it enters into. I argue that it is impossible to draw a principled distinction between logical and non-logical concepts, and hence that the content of ...
Horsey, Richard
core +1 more source
Weak distinction and the optimal definition of causal continuity
, 2008 Causal continuity is usually defined by imposing the conditions (i) distinction and (ii) reflectivity. It is proved here that a new causality property which stays between weak distinction and causality, called feeble distinction, can actually replace ...
Beem J K +6 more
core +1 more source