Results 61 to 70 of about 1,313,618 (334)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Fast Distributed PageRank Computation
, 2015 Over the last decade, PageRank has gained importance in a wide range of applications and domains, ever since it first proved to be effective in determining node importance in large graphs (and was a pioneering idea behind Google's search engine).
Andersen +23 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Asynchronous Distributed Semi-Stochastic Gradient Optimization
, 2015 With the recent proliferation of large-scale learning problems,there have been a lot of interest on distributed machine learning algorithms, particularly those that are based on stochastic gradient descent (SGD) and its variants.
Kwok, James T. +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Two‐stage personalized federated learning based on sparse pretraining
Electronics Letters, 2023 Aiming at solving the performance degradation of federated learning (FL) under heterogeneous data distribution, personalized FL (PFL) was proposed. It is designed to produce a dedicated model for each client.
Tong Liu +6 more
doaj +1 more source
On Derandomizing Local Distributed Algorithms
, 2018 The gap between the known randomized and deterministic local distributed algorithms underlies arguably the most fundamental and central open question in distributed graph algorithms.
Ghaffari, Mohsen +2 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Sensors, 2020 Efficient data aggregation is crucial for mobile wireless sensor networks, as their resources are significantly constrained. Over recent years, the average consensus algorithm has found a wide application in this technology.
Martin Kenyeres, Jozef Kenyeres
doaj +1 more source
Misaka: Interactive Swarm Testbed for Smart Grid Distributed Algorithm Test and Evaluation [PDF]
, 2020 Tingliang Zhang +3 more
openalex +1 more source