Results 101 to 110 of about 574,204 (308)

Metadata queries for complex database systems [PDF]

, 2004
Federated Database Management Systems (FDBS) are very complex. Component databases can be heterogeneous, autonomous and distributed, accounting for these different characteristics in building a FDBS is a difficult engineering problem.
O'Connor, Gerald
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Performance analysis of static locking in replicated distributed database systems

, 1991
Data replication and transaction deadlocks can severely affect the performance of distributed database systems. Many current evaluation techniques ignore these aspects, because it is difficult to evaluate through analysis and time consuming to evaluate ...
Kuang, Yinghong, Mukkamala, Ravi
core  

Semi-Distributed Vacuuming Model on Temporal Database (SDVMT) [PDF]

Database Systems Journal, 2012
Temporal database is one of the most common types of databases. Portfolio management, accounting, storage, treatment management systems, aerology systems and scheduling are applications which their data have time references.
Mohammad Shabanali FAMI, Elham Shabanali FAMI, Mohammad Ali MONTAZERI, Mohammad Taghi ISAAI   +3 more
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Adaptive query-based sampling of distributed collections

, 2006
As part of a Distributed Information Retrieval system a de-scription of each remote information resource, archive or repository is usually stored centrally in order to facilitate resource selection.
Fabio Crestani, Azzopardi, L., Crestani, F., Leif Azzopardi, Mark Baillie, Baillie, M., Crestani, Fabio, Azzopardi, Leif, Baillie, Mark   +8 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

BioSimGrid: a distributed database for biomolecular simulations

, 2003
Biomolecular simulations provide data on the conformational dynamics and energetics of complex biomolecular systems. We aim to exploit the e-science infrastructure developing in the UK to enable large scale analysis of the results of such simulations. In
Essex, Jonathan, Kaihsu Tai, Cox, S., Jeffreys, Paul, Ng, Muan Hong, Murdock, S., Ng, M.H., Steve Johnston, Muan Hong Ng, Mark S. P. Sansom, Cox, Simon, Stuart Murdock, Sansom, Mark S.P., Murdock, Stuart, Johnston, S., Tai, K., Jeffreys, P., Wu, B., Wu, Bing, Hans Fangohr, Jonathan Essex, Johnston, Steven, Fangohr, Hans, Sansom, M., Tai, Kaishu, Sansom, Mark S. P., Johnston, Steve, Simon Cox, Essex, J.W., Fangohr, H., Bing Wu, Paul Jeffreys   +31 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source