Results 61 to 70 of about 2,106,567 (294)

Mars Climate Database version 5 [PDF]

, 2012
The Mars Climate Database (MCD) is a database of meteorological fields derived from General Circulation Model (GCM) numerical simulations [2,4] of the Martian atmosphere and validated using available observational data.
Chauffray, J.-Y., Colaitis, A., Desjean, M.-C., Forget, F., Gonzalez-Galindo, F., Huot, J.-P., Lefevre, F., Lewis, S. R., Lopez-Valverde, M. A., Madeleine, J.-B., Millour, E., Montabone, L., Montmessin, F., Navarro, T., Read, P. L., Spiga, A.   +15 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

GEOBARN: A Practical Grid Geospatial Database System

Advances in Electrical and Computer Engineering, 2009
Recently, more and more geospatial data are generated and distributed with the promising data acquirement techniques like satellite imaging and digital cartography.
XIE, X., FANG, Y., HUANG, Z., PAN, M.
doaj   +1 more source

Database Consistency Using Update-Ordering in Distributed Databases

Journal of Algorithms & Computational Technology, 2007
Database consistency is one of the major issues in replicated database in distributed database systems. The logical design for the replicated nodes and the transaction management mechanism are two aspects that give a serious impact to the performance and
W. N. Shuhadah, M. Mat Deris, A. Noraziah, M.Y. Saman, M. Rabiei   +4 more
doaj   +1 more source

ART and ARTMAP Neural Networks for Applications: Self-Organizing Learning, Recognition, and Prediction [PDF]

, 1996
ART and ARTMAP neural networks for adaptive recognition and prediction have been applied to a variety of problems. Applications include parts design retrieval at the Boeing Company, automatic mapping from remote sensing satellite measurements, medical ...
Carpenter, Gail A., Gjaja, Marin N., Gopal, Sucharita, Markuzon, Natalya, Woodcock, Curtis E.   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Record matching method based on local CON model in distributed database

Tongxin xuebao, 2011
For existing record matching methods needed much artificial participation of experts or depend on heuristic rules heavily,and they could not handle the problem of large-scale data,A record matching method based on the local CON model was proposed.The ...
LI Jiao1, LIU Quan1, FU Qi-ming1, WANG Ting-gang2   +3 more
doaj  

Development of a distributed knowledge-based system [PDF]

, 2001
This paper describes the development of a distributed knowledge-based system. A software system, namely Distributed Algorithmic and Rule-based Blackboard System (DARBS), was developed from its predecessor ARBS, which lacked the distributed computing ...
Hopgood, AA, Nolle, L, Wong, KCP
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source