Results 91 to 100 of about 2,018,156 (259)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Can distributed delays perfectly stabilize dynamical networks? [PDF]

, 2008
Signal transmission delays tend to destabilize dynamical networks leading to oscillation, but their dispersion contributes oppositely toward stabilization.
Shinomoto, Shigeru, Omi, Takahiro
core   +1 more source

Existence and attractivity of periodic solutions to Cohen-Grossberg neural network with distributed delays

Electronic Journal of Differential Equations, 2005
We study the existence and exponential attractivity of periodic solutions to Cohen-Grossberg neural network with distributed delays. Our results are obtained by applying the continuation theorem of coincidence degree theory and a general Halanay ...
Yongkun Li, Lifei Zhu
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

The influence of socio-economic deprivation on tuberculosis treatment delays in England, 2000-2005 [PDF]

, 2009
This study investigates the association between socio-economic deprivation and tuberculosis (TB) treatment delays in England, 2000–2005. Patients reported to the Enhanced TB Surveillance system were assigned a deprivation score based on residential ...
Kruijshaar, M. E., Jones, J. A., French, CE, French, C E, Kruijshaar, ME, Jones, J A, Jones, JA, Abubakar, I., Abubakar, I, Kruijshaar, M E, French, C. E.   +10 more
core   +1 more source

Behavior of impulsive fuzzy cellular neural networks with distributed delays

Electronic Journal of Differential Equations, 2007
In this paper, we investigate a generalized model of fuzzy cellular neural networks with distributed delays and impulses. By employing the theory of topological degree, M-matrix and Lypunov functional, we find sufficient conditions for the existence ...
Kelin Li, Zuoan Li, Qiankun Song
doaj  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Uniqueness of traveling wave solutions for non-monotone cellular neural networks with distributed delays

Electronic Journal of Differential Equations, 2017
In this article, we study the uniqueness of traveling wave solutions for non-monotone cellular neural networks with distributed delays. First we establish a priori asymptotic behavior of the traveling wave solutions at infinity.
Hui-Ling Zhou, Zhixian Yu
doaj  

Observer-Based H_∞ Control for Uncertain Neutral Systems with Distributed Delays

Mathematics
This paper addresses the observer-based H∞ control problem for a class of uncertain neutral systems with distributed delays subject to norm-bounded time-varying uncertainties and bounded time-varying delays.
Khwanchai Kunwai, Thaned Rojsiraphisal, Supreedee Dangskul, Kamonwan Kocharoen   +3 more
doaj   +1 more source