Results 111 to 120 of about 56,189 (268)

A Generalization of the Gamma Distribution

The Annals of Mathematical Statistics, 1962
This paper concerns a generalization of the gamma distribution, the specific form being suggested by Liouville's extension to Dirichlet's integral formula [3]. In this form it also may be regarded as a special case of a function introduced by L. Amoroso [1] and R. d'Addario [2] in analyzing the distribution of economic income.
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Distribution-Conditional Generation: From Class Distribution to Creative Generation

CoRR
Text-to-image (T2I) diffusion models are effective at producing semantically aligned images, but their reliance on training data distributions limits their ability to synthesize truly novel, out-of-distribution concepts. Existing methods typically enhance creativity by combining pairs of known concepts, yielding compositions that, while out-of ...
Fu Feng, Yucheng Xie, Xu Yang 0021, Jing Wang 0113, Xin Geng 0001   +4 more
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Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Gas emission optimization and optimal energy management of a microgrid operating by renewable and sustainable generation systems

Algerian Journal of Signals and Systems
The economic operation of electric energy generating systems is one of predominant problems in energy systems. Due to the need for better reliability, high energy quality, lower losses, lower cost and clean environment, the application of renewable and ...
Nabil MEZHOUD, Bilel AYACHI, Ahmed BAHRI   +2 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Enhanced current differential protection principle based on anti-interference coefficient for distribution network

Diance yu yibiao
With the widespread integration of distributed generators, distribution network is altered from simple radial network to multi-terminal active network.
ZHU Bingquan, DU Haoliang, FANG Yudong, CHEN Hao, XU Wencheng, LIU Sumei   +5 more
doaj   +1 more source

Federated distributed key generation

Future Generation Computer Systems
Distributed Key Generation (DKG) underpins threshold cryptography in many systems, including decentralized wallets, validator key ceremonies, cross-chain bridges, threshold signatures, secure multiparty computation, and internet voting. Classical ($t$,$n$)-DKG assumes a fixed group of n parties and a global threshold $t$, requiring full and timely ...
Stanislaw Baranski, Julian Szymanski
openaire   +2 more sources