Results 91 to 100 of about 59,883 (268)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Comparison of Sine-Cosine and Bat Algorithm for Distributed Generation Placement

Jurnal Nasional Teknik Elektro dan Teknologi Informasi
The enhancement of electricity distribution is a crucial factor in supporting sustainable development and reducing energy access inequality. To ensure the reliability and stability of energy systems, the integration of distributed generation (DG) has a ...
Lindiasari Martha Yustika, Jangkung Raharjo, Rifki Rahman Nur Ikhsan, I Gede Putu Oka Indra Wijaya   +3 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Impact of DG Access on Microgrid Current Protection

发电技术, 2019
When distributed generator (DG) is connected to the microgrid, the microgrid will change from single source system to multiple source system, which will change the power flow distribution and fault short-circuit current flow of the original network, the ...
Jing DING, Xin WANG, Shuwen ZHENG, Yu CHEN, Shiqi SUN   +4 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A Multivariate Generalization of the Generalized Poisson Distribution [PDF]

ASTIN Bulletin, 2000
AbstractThis paper proposes a multivariate generalization of the generalized Poisson distribution. Its definition and main properties are given. The parameters are estimated by the method of moments.
openaire   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Studi Skema Proteksi Adaptive Over Current Pada Jaringan Distribusi Dengan Pembangkit Tersebar Menggunakan Genetic Algorithm

Jurnal Teknik ITS, 2017
Dengan berkembangnya renewable energy, seperti energi matahari , energi angin dan air untuk kedepannya akan menjadi sumber energi yang bersih yang mampu menambah daya listrik. Saat ini pembangkit tenaga listrik pada umumnya menggunakan sumber energi batu
Mukhamad Subkhi, Margo Pujiantara, Sjamsjul Anam   +2 more
doaj