Results 71 to 80 of about 59,883 (268)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Improvements in Bidirectional Power-Flow Balancing and Electric Power Quality of a Microgrid with Unbalanced Distributed Generators and Loads by Using Shunt Compensators

Energies, 2018
Improper connections of unbalanced distributed generators (DGs) and loads in a three-phase microgrid cause unbalanced and bidirectional power flow problems. The unbalanced DGs and loads may also aggravate the electric power quality (EPQ), such as voltage
Wei-Neng Chang, Chia-Min Chang, Shao-Kang Yen   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Longitudinal Protection Scheme for Distribution Network with Distributed Power Based on Amplitude and Phase Characteristics of Fault Sequence Current

Taiyuan Ligong Daxue xuebao
Purposes With the continuous access of distributed generator (DG) in the traditional distribution network, it has brought serious challenges to the distribution network protection configuration.
Yang YANG, Shengwen LI, Xiaoqian CHEN, Wenping QIN, Rui LI, Yizhao LIU, Yitian CAI   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Distributional Generalization: A New Kind of Generalization

CoRR, 2020
We introduce a new notion of generalization -- Distributional Generalization -- which roughly states that outputs of a classifier at train and test time are close *as distributions*, as opposed to close in just their average error. For example, if we mislabel 30% of dogs as cats in the train set of CIFAR-10, then a ResNet trained to interpolation will ...
Preetum Nakkiran, Yamini Bansal
openaire   +3 more sources

A Conservation Voltage Reduction Scheme for a Distribution Systems with Intermittent Distributed Generators

Energies, 2016
In this paper, a conservation voltage reduction (CVR) scheme is proposed for a distribution system with intermittent distributed generators (DGs), such as photovoltaics and wind turbines.
Pyeong-Ik Hwang, Seung-Il Moon, Seon-Ju Ahn   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Hierarchical energy management mechanisms for an electricity market with microgrids

The Journal of Engineering, 2014
This study addresses a micro-grid electricity market (MGEM) with day-ahead (DA) and real-time market mechanisms integrated. The bidding mechanisms for the market are described in this study, considering the generation cost of different distributed energy
Hong-Tzer Yang, Jian-Tang Liao
doaj   +1 more source