A port-Hamiltonian approach to modeling and interconnections of canal systems [PDF]
We show how the port-Hamiltonian formulation of distributed parameter systems, which incorporates energy flow through the boundary of the spatial domain of the system, can be used to model networks of canals and study interconnections of such systems. We
Pasumarthy, Ramkrishna +1 more
core +4 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
In this paper, a control scheme based on state prediction is proposed for a class of nonlinear systems subject to input delay and external disturbance. Firstly, as for constant input delay, an improved control scheme that combining state prediction with ...
Bing Zhu, Mou Chen, Tao Li
doaj +1 more source
Local Control of Reactive Power by Distributed Photovoltaic Generators [PDF]
High penetration levels of distributed photovoltaic (PV) generation on an electrical distribution circuit may severely degrade power quality due to voltage sags and swells caused by rapidly varying PV generation during cloud transients coupled with the ...
Backhaus, Scott +3 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Control technology development [PDF]
The main objectives of the control technology development task are given in the slide below. The first is to develop control design techniques based on flexible structural models, rather than simple rigid-body models.
Schaechter, D. B.
core +1 more source
Parallel accelerated cyclic reduction preconditioner for three-dimensional elliptic PDEs with variable coefficients [PDF]
We present a robust and scalable preconditioner for the solution of large-scale linear systems that arise from the discretization of elliptic PDEs amenable to rank compression.
Chávez, Gustavo +3 more
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Two-Threshold Model for Scaling Laws of Non-Interacting Snow Avalanches
The sizes of snow slab failure that trigger snow avalanches are power-law distributed. Such a power-law probability distribution function has also been proposed to characterize different landslide types.
C. Dussauge +11 more
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source

