Results 91 to 100 of about 1,566,466 (297)
An approximation theory for the identification of nonlinear distributed parameter systems [PDF]
An abstract approximation framework for the identification of nonlinear distributed parameter systems is developed. Inverse problems for nonlinear systems governed by strongly maximal monotone operators (satisfying a mild continuous dependence condition ...
Banks, H. T. +2 more
core +1 more source
PaPaS: A Portable, Lightweight, and Generic Framework for Parallel Parameter Studies
, 2018 The current landscape of scientific research is widely based on modeling and simulation, typically with complexity in the simulation's flow of execution and parameterization properties.
Day, Judy +4 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
On compactness of admissible parameter sets: Convergence and stability in inverse problems for distributed parameter systems [PDF]
A series of numerical examples is reported and several algorithms compared for estimation of coefficients in differential equation models. Unconstrained, constrained and Tikhonov regularization methods are tested for their behavior with regard to both ...
Banks, H. T., Iles, D. W.
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Ain Shams Engineering JournalThis paper presents an optimal fault-tolerant control (FTC) method for dynamic systems with distributed fault parameter uncertainty. According to the distributed characteristic of the fault parameter uncertainty domain and insufficient fault information,
Dan Du, Zetao Li
doaj +1 more source
A Two-Threshold Model for Scaling Laws of Non-Interacting Snow Avalanches
, 2004 The sizes of snow slab failure that trigger snow avalanches are power-law distributed. Such a power-law probability distribution function has also been proposed to characterize different landslide types.
C. Dussauge +11 more
core +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source