Results 91 to 100 of about 634,284 (286)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
The Evolution of Equid Monodactyly: A Review Including a New Hypothesis
Frontiers in Ecology and Evolution, 2019 The traditional story of horse evolution is well-known: over time, horses became larger, they attained higher-crowned teeth, and they changed from having three toes (tridactyly) to a single toe (monodactyly). Evolution is often perceived as a progression
Christine M. Janis +2 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Actinomyces spp. gene expression in root caries lesions
Journal of Oral Microbiology, 2016 Background: The studies of the distribution of Actinomyces spp. on carious and non-carious root surfaces have not been able to confirm the association of these bacteria with root caries, although they were extensively implicated as a prime suspect in ...
Naile Dame-Teixeira +5 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Bounds For The Tail Distribution Of The Sum Of Digits Of Prime Numbers
, 2012 Let s_q(n) denote the base q sum of digits function, which for ...
Naslund, Eric
core
Large sieve inequalities for exceptional Maass forms and the greatest prime factor of $n^2+1$
Forum of Mathematics, PiWe prove new large sieve inequalities for the Fourier coefficients $\rho _{j\mathfrak {a}}(n)$ of exceptional Maass forms of a given level, weighted by sequences $(a_n)$ with sparse Fourier transforms – including two key types of sequences ...
Alexandru Pascadi
doaj +1 more source
Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation
Frontiers in Immunology, 2017 Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an attractive option to increase NK cells in numbers and to improve their
Markus Granzin +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Generalization of Bertrand's Postulate for Gaussian Primes
, 2019 Bertrand's Postulate states about the prime distribution for the real numbers. The generalization of Bertrand's Postulate was proved by Das et al. [Arxiv 2018].
Das, Madhuparna
core