Results 81 to 90 of about 633,827 (270)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Actinomyces spp. gene expression in root caries lesions
Journal of Oral Microbiology, 2016 Background: The studies of the distribution of Actinomyces spp. on carious and non-carious root surfaces have not been able to confirm the association of these bacteria with root caries, although they were extensively implicated as a prime suspect in ...
Naile Dame-Teixeira +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Large sieve inequalities for exceptional Maass forms and the greatest prime factor of $n^2+1$
Forum of Mathematics, PiWe prove new large sieve inequalities for the Fourier coefficients $\rho _{j\mathfrak {a}}(n)$ of exceptional Maass forms of a given level, weighted by sequences $(a_n)$ with sparse Fourier transforms – including two key types of sequences ...
Alexandru Pascadi
doaj +1 more source
Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation
Frontiers in Immunology, 2017 Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an attractive option to increase NK cells in numbers and to improve their
Markus Granzin +8 more
doaj +1 more source
Bounds For The Tail Distribution Of The Sum Of Digits Of Prime Numbers
, 2012 Let s_q(n) denote the base q sum of digits function, which for ...
Naslund, Eric
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Constructing Carmichael numbers through improved subset-product algorithms
, 2013 We have constructed a Carmichael number with 10,333,229,505 prime factors, and have also constructed Carmichael numbers with k prime factors for every k between 3 and 19,565,220. These computations are the product of implementations of two new algorithms
Alford, W. R. +3 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Distribution of Composite Numbers and Determination of Prime Numbers
, 2021 Integer is either a composite number or a prime number. Therefore, detecting composite numbers is important for solving prime numbers. The study of prime numbers, apart from satisfying human curiosity, can be very important. In this article, the order of composite numbers has been detected. And explained with a simple method and a simple function. And,
openaire +4 more sources