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Distribution of Composite Numbers and Determination of Prime Numbers
, 2021 Integer is either a composite number or a prime number. Therefore, detecting composite numbers is important for solving prime numbers. The study of prime numbers, apart from satisfying human curiosity, can be very important. In this article, the order of composite numbers has been detected. And explained with a simple method and a simple function. And,
openaire +4 more sources
The Distribution of Prime Numbers and Finding the Factor of Composite Numbers without Searching
, 2015 In this paper, there are 5 sections of tables represented by 5 linear sequence functions. There are two one-variable sequence functions that they are able to represent all prime numbers.
D. Jenber
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Constructing Carmichael numbers through improved subset-product algorithms
, 2013 We have constructed a Carmichael number with 10,333,229,505 prime factors, and have also constructed Carmichael numbers with k prime factors for every k between 3 and 19,565,220. These computations are the product of implementations of two new algorithms
Alford, W. R. +3 more
core
On some new questions on the distribution of prime numbers
, 1948 have infinitely many solutions. If the well known hypothesis about prime twins is true, that is, if the equation pn+i—pn — 2 has infinitely many solutions, (1) and (2) of course are trivially satisfied.
P. Erdös, P. Turán
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
South African Journal of Business Management, 2008 This paper explores the transferability and application of business-driven strategic thinking to that of a public sector context, namely national mapping organisations.
M. Denner, H. Oosthuizen
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source