Results 51 to 60 of about 93,875 (269)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

On properties of the numbers coprime with the primes up to p_n

open access: yesLe Matematiche, 2006
In this paper we investigate about the effective distribution of the numbers coprime with the primes up to p_n . More precisely we prove that these numbers form a periodically monotone sequence . Then we examine some properties of this sequence which, in
Giovanni Fiorito
doaj  

On the irregularity of the distribution of the sums of pairs of odd primes

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2002
Let P2(n) denote the number of ways of writing n as a sum of two odd primes. We support a conjecture of Hardy and Littlewood concerning P2(n) by showing that it holds in a certain “average” sense. Thereby showing the irregularity of P2(n).
George Giordano
doaj   +1 more source

Predicting Maximal Gaps in Sets of Primes

open access: yesMathematics, 2019
Let q > r ≥ 1 be coprime integers. Let P c = P c ( q , r , H ) be an increasing sequence of primes p satisfying two conditions: (i) p ≡ r (mod q) and (ii) p starts a prime k-tuple with a given pattern H ...
Alexei Kourbatov, Marek Wolf
doaj   +1 more source

Diophantine definability of infinite discrete non-archimedean sets and Diophantine models over large subrings of number fields

open access: yes, 2004
We prove that infinite p-adically discrete sets have Diophantine definitions in large subrings of some number fields. First, if K is a totally real number field or a totally complex degree-2 extension of a totally real number field, then there exists a ...
Poonen, Bjorn, Shlapentokh, Alexandra
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

On the distribution of Hawkins’ random “primes” [PDF]

open access: yesJournal de théorie des nombres de Bordeaux, 2009
Hawkins introduced a probabilistic version of Erathosthenes’ sieve and studied the associated sequence of random “primes” (p k ) k≥1 . Using various probabilistic techniques, many authors have obtained sharp results concerning these random “primes”, which are often in agreement with certain classical theorems or conjectures for prime numbers.
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Tympanic Membrane Collagen Expression by Dynamically Cultured Human Mesenchymal Stromal Cell/Star-Branched Poly(ε-Caprolactone) Nonwoven Constructs

open access: yesApplied Sciences, 2020
The tympanic membrane (TM) primes the sound transmission mechanism due to special fibrous layers mainly of collagens II, III, and IV as a product of TM fibroblasts, while type I is less represented.
Stefania Moscato   +10 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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