Results 61 to 70 of about 93,875 (269)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Distribution of constant terms of irreducible polynomials in ℤₚ[x] whose degree is a product of two distinct odd primes [PDF]

Notes on Number Theory and Discrete Mathematics
We obtain explicit formulas for the number of monic irreducible polynomials with prescribed constant term and degree q₁q₂ over a finite field, where q₁ and q₂ are distinct odd primes. These formulas are derived from work done by Yucas.
Sarah C. Cobb, Michelle L. Knox, Marcos Lopez, Terry McDonald, Patrick Mitchell   +4 more
doaj   +1 more source

On product sets of arithmetic progressions

Discrete Analysis, 2023
On product sets of arithmetic progressions, Discrete Analysis 2023:10, 31 pp. The _multiplication table problem_ is a very simply stated question of Erdős: how many numbers appear in the multiplication table of the numbers from 1 to $n$?
Max Wenqiang Xu, Yunkun Zhou
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features

iScience, 2019
Summary: Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that
Abhijeet Pataskar, Willem Vanderlinden, Johannes Emmerig, Aditi Singh, Jan Lipfert, Vijay K. Tiwari   +5 more
doaj   +1 more source

Distribution Modulo One of αp^γ + β for Special Classes of Primes

Axioms
Let α,β∈R with α≠0, and let γ∈(0,5/6). Define the set M1 to consist of primes p such that p+2 is almost prime, and let M2 be the set of primes of the form p=a2+b2+1.
Atanaska Georgieva, Tatiana L. Todorova
doaj   +1 more source

Synthesis of Iron Oxide Yellow from Spent Pickling Solutions

MATEC Web of Conferences, 2016
This paper demonstrates a simple environment-friendly synthesis route of iron oxide yellow (α-FeOOH) using spent pickling solutions as raw material. After abundant laboratory experiments, we finally pinned down the best procedure.
Wan Guangqin, Lv Feifei, Yang Yaqiang, Wang Xingyao   +3 more
doaj   +1 more source