Results 101 to 110 of about 4,872,467 (307)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An electro-thermal modeling of distribution transformer for hottest spot evaluation under photovoltaic-induced harmonics

International Journal of Renewable Energy Development
Elevated winding insulation temperature, driven by harmonic distortions, is a key factor in transformer lifespan reduction. Conventional models often oversimplify the effect of combined current and voltage harmonics.
Muhammad Haziq Mohd Wazir, Dalila Mat Said, Norazliani Md Sapari, Mohamed Shahriman Mohamed Yunus, Zaris Izzati Mohd Yassin   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Maintenance Strategy for Optimizing Distribution Transformer Life Cycle Cost [PDF]

, 2013
During the operation, the distribution transformer performance will deteriorate. The maintenance is an essential task in enhancing the safety of distribution transformer.
Xu, Bo, Li, Ming, He, Zhangzhou, Qiu, Gefei, Ye, Bo, Xuan, Lei   +5 more
core   +1 more source

A power quality equalization compensation algorithm for medium-voltage distribution transformer-side power quality considering ordered clustering of incremental loads [PDF]

AIP Advances
To adapt to the characteristics of continuity, dynamics, and uneven distribution of incremental loads and to ensure the power quality of the medium-voltage (MV) distribution transformer terminal, we study the power quality equalization compensation ...
Rui Zhao, Guiping He, Yanli Xiao, Bin Bai, Chunye Bai   +4 more
doaj   +1 more source

On continuous wavelet transforms of distributions

Applied Mathematics Letters, 2011
Fix a spherically symmetric wavelet \(\psi\) satisfying an admissibility condition and, as usual, for any \(b\in\mathbb R^n\) and \(a>0\), denote \(\psi^{a,b}(x) = a^{-n/2}\psi(\frac{x-b}{a})\). The continuous wavelet transform of a compactly supported distribution \(f\) associated to \(\psi\) is given by \((Tf)(a,b)= \langle f,\overline{\psi^{a,b ...
Ravshan Ashurov, Almaz Butaev
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Partial Discharge Location within a Transformer Winding using Principal Component Analysis

, 2011
Partial discharge (PD) may occur in a transformer winding due to ageing processes, operational over stressing or defects introduced during manufacture. The presence of PD does not necessarily indicate imminent failure of the transformer but it will lead ...
Abd Rahman, M S, Hao, L, Lewin, P L
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source