Results 81 to 90 of about 765 (256)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Distributionally robust Lyapunov–Barrier Networks for safe and stable control under uncertainty

Results in Control and Optimization
This paper addresses the challenge of simultaneously achieving stability and safety in nonlinear control systems subject to uncertain parameters. We propose distributionally robust Lyapunov–Barrier networks (DR-LBNs), a novel framework that unifies ...
Ali Baheri
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Distributionally Robust Energy Optimization with Renewable Resource Uncertainty

Mathematics
With the increasing prevalence of intermittent power generation, the volatility, intermittency, and randomness of renewable energy pose significant challenges to the planning and operation of distribution networks.
Zhangyi Wang, Rui Cao, Dan Tang, Chunsheng Wang, Xiaoyu Liu, Weiguang Hu   +5 more
doaj   +1 more source

A distributionally robust optimization approach for airline integrated recovery under in-flight pandemic transmission risks. [PDF]

Transp Res Part C Emerg Technol, 2023
Xu Y, Wandelt S, Sun X.
europepmc   +1 more source

Distributionally Robust Token Optimization in RLHF

CoRR
Large Language Models (LLMs) tend to respond correctly to prompts that align well with the data they were trained and fine-tuned on. Yet, small shifts in wording, format, or language can trigger surprisingly large failures, especially on multi-step reasoning problems.
Yeping Jin, Jiaming Hu, Ioannis Ch. Paschalidis   +2 more
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A new distributionally robust reward-risk model for portfolio optimization

Open Mathematics
A new distributionally robust ratio optimization model is proposed under the known first and second moments of the uncertain distributions. In this article, both standard deviation (SD) and conditional value-at-risk (CVaR) are used to measure the risk ...
Zhou Yijia, Xu Lijun
doaj   +1 more source