Results 61 to 70 of about 765 (256)
DronesThis paper addresses the cooperative task assignment problem for heterogeneous unmanned aerial vehicles with time windows considering uncertain fuel consumption. In the scenario where probabilistic fuel consumption exists and its distribution needs to be
Zhichao Gao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Future InternetEarthquake disasters often cause communication base stations to fail, severely hindering rescue operations and information transmission. While traditional air-ground collaborative emergency communication systems can rapidly restore communications, they ...
Miao Miao, Wei Wang, Xiaokai Lian
doaj +1 more source
Calibration of Distributionally Robust Empirical Optimization Models [PDF]
Operations Research, 2017 In “Calibration of Robust Empirical Optimization Models,” Gotoh, Kim, and Lim study the statistical properties of ɸ-divergence distributionally robust optimization with concave rewards. They show that worst-case sensitivity of the expected reward to deviations from the nominal is equal to the in-sample variance and that significant out-of-sample ...
Jun-ya Gotoh +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
IET Renewable Power Generation, 2022 The new technologies, such as soft open points (SOPs) and demand response (DR), offer original approaches to stabilize the system operation and accommodate the high penetration of distributed generators (DGs).
Hong Liu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Wasserstein Distributionally Robust Regret Optimization
CoRRDistributionally robust optimization (DRO) is widely used for decision-making under uncertainty, but its adversarial focus on worst-case loss can lead to overly conservative policies. To mitigate this, we study ex-ante Distributionally Robust Regret Optimization (DRRO) with Wasserstein ambiguity sets, designed to balance robustness with upside ...
Lukas-Benedikt Fiechtner +1 more
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source