Results 91 to 100 of about 691,837 (293)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Adropin: a key component and potential gatekeeper of metabolic disturbances in policystic ovarian syndrome [PDF]

, 2014
Burak Oğulcan Yıldırım, Ömer Çelik, Suna Aydın   +2 more
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Detection of forest disturbance across California using deep-learning on PlanetScope imagery

Frontiers in Remote Sensing
California forests have recently experienced record breaking wildfires and tree mortality from droughts, However, there is inadequate monitoring, and limited data to inform policies and management strategies across the state.
Griffin Carter, Fabien H. Wagner, Fabien H. Wagner, Fabien H. Wagner, Ricardo Dalagnol, Ricardo Dalagnol, Ricardo Dalagnol, Sophia Roberts, Alison L. Ritz, Alison L. Ritz, Sassan Saatchi, Sassan Saatchi, Sassan Saatchi   +12 more
doaj   +1 more source

Identifying potential measures of stress and disturbance during a captive to wild African elephant reintegration

, 2023
Yolanda Pretorius, Tamara Eggeling, André Ganswindt   +2 more
openalex   +2 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

The Physiological Cost of Being Hot: High Thermal Stress and Disturbance Decrease Energy Reserves in Dragonflies in the Wild

Biology
Anthropogenic disturbance alters macro- and microclimatic conditions, often increasing ambient temperatures. These changes can strongly affect insects, particularly those experiencing high thermal stress (i.e., large differences between body and ...
Eduardo Ulises Castillo-Pérez, Angélica S. Ensaldo-Cárdenas, Catalina M. Suárez-Tovar, José D. Rivera-Duarte, Daniel González-Tokman, Alex Córdoba-Aguilar   +5 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Daily Variation in the Feeding Activity of Pacific Crown-of-Thorns Starfish (Acanthaster cf. solaris)

Biology
The ecological impact of crown-of-thorns starfish (CoTS; Acanthaster spp.) on coral reefs is intrinsically linked to their feeding behaviour. Management thresholds designed to mitigate coral loss driven by elevated densities of crown-of-thorns starfish ...
Josie F. Chandler, Deborah Burn, Will F. Figueira, Peter C. Doll, Abby Johandes, Agustina Piccaluga, Morgan S. Pratchett   +6 more
doaj   +1 more source