Disruption of reducing pathways is not essential for efficient disulfide bond formation in the cytoplasm of
Microbial Cell Factories, 2010 Background The formation of native disulfide bonds is a complex and essential post-translational modification for many proteins. The large scale production of these proteins can be difficult and depends on targeting the protein to a compartment in which ...
Hatahet Feras +3 more
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Structural and Catalytic Roles of the Disulfide Bonds Cys19–Cys154 and Cys134–Cys199 in Trypsin-like Proteases: Evolutionary Insights for Disulfide Bond Acquisition [PDF]
MoleculesTrypsin is one of the most extensively studied enzymes in biochemistry. However, little information is available on the role of the disulfide bonds to establish the correct conformation and enzyme activity during molecular evolution.
Maiko Minakata +9 more
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In Silico Modeling of Myelin Oligodendrocyte Glycoprotein Disulfide Bond Reduction by Phosphine-Borane Complexes [PDF]
PharmaceuticalsBackground: Neurodegenerative diseases can cause vision loss by damaging retinal ganglion cells in the optic nerve. Novel phosphine-borane compounds (PBs) can protect these cells from oxidative stress via the reduction of disulfide bonds.
Raheem Remtulla +2 more
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Validation of the Intermolecular Disulfide Bond in Caspase-2 [PDF]
BiologyCaspases are a family of proteins involved in cell death. Although several caspase members have been well characterized, caspase-2 remains enigmatic. Caspase-2 has been implicated in several phenotypes, but there has been no consensus in the field about ...
Megan E. Amason +4 more
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Stability and functional consequences of disulfide bond engineering in Aspergillus flavus uricase [PDF]
Scientific ReportsDisulfide bond engineering is a promising strategy for enhancing the stability and functional lifespan of enzymes in therapeutic and industrial applications.
Mohammad Reza Rahbar +6 more
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QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma [PDF]
Advanced ScienceDisulfide bond modification is critical in maintaining protein structure and activity, but its roles in regulating tumor stemness and chemoresistance remain underexplored.
Wo‐Ming Chen +12 more
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Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System [PDF]
International Journal of NanomedicineWeiran Ma,1,2 Xiaoying Wang,2 Dongqi Zhang,3 Xupeng Mu1 1Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, People’s Republic of China; 2Jilin University School of Pharmaceutical Sciences, Changchun, 130021 ...
Ma W, Wang X, Zhang D, Mu X
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Scientific Reports, 2021 Generally, intermolecular disulfide bond contribute to the conformational protein stability. To identify sites where intermolecular disulfide bond can be introduced into the Fab’s constant domain of the therapeutic IgG, Fab mutants were predicted using ...
Hitomi Nakamura +4 more
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The name's bond……disulfide bond [PDF]
Current Opinion in Structural Biology, 2007 A repeating theme in the structural biology of disulfide oxidants and isomerases is the extraordinary architectural similarity between functionally related proteins from prokaryotes and eukaryotes. The recently determined structure of full-length yeast protein disulfide isomerase (PDI) reveals a U-shaped molecule with two redox-active sites. It bears a
Heras, Begona +3 more
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Foods, 2023 Wheat, maize, cassava, mung bean and sweet potato starches have often been added to dough systems to improve their hardness. However, inconsistent effects of these starches on the dough quality have been reported, especially in refrigerated dough.
Yu Zhou +4 more
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