Results 211 to 220 of about 96,012 (310)

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond. [PDF]

J Biol Chem
van der Velden TT, Kayastha K, Waterham CYJ, Brünle S, Jeuken LJC.   +4 more
europepmc   +1 more source

A C-terminal disulfide bond in the copper-containing amine oxidase from pea seedlings violates the twofold symmetry of the molecular dimer

, 2006
Anthony P. Duff, Eric M. Shepard, David B. Langley, David M. Dooley, Hans C. Freeman, J.M. Guss   +5 more
openalex   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Experimental and Computational Studies on Domain-Swapped Structure Stabilization of an Antibody Light Chain by Disulfide Bond Introduction. [PDF]

J Med Chem
Fitriana W, Sakai T, Duan L, Hengphasatporn K, Shigeta Y, Mashima T, Uda T, Hifumi E, Hirota S.   +8 more
europepmc   +1 more source

Supplementary Table 1 from DR5 Disulfide Bonding Functions as a Sensor and Effector of Protein Folding Stress

Mary E. Law, Zaafir M. Dulloo, Samantha R. Eggleston, Gregory P. Takacs, Grace M. Alexandrow, Young Il Lee, Mengxiong Wang, Brian Hardy, Hanyu Su, Bianca Forsyth, Parag Das, Pran K. Datta, Chi‐Wu Chiang, Abhisheak Sharma, Raju S. Kanumuri, Olga A. Guryanova, Jeffrey K. Harrison, Boaz Tirosh, Ronald K. Castellano, Brian K. Law   +19 more
openalex   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Prior disulfide bond-mediated Ser/Thr ligation. [PDF]

Chem Sci
Liu H, Chow HY, Liu J, Shi P, Li X.
europepmc   +1 more source

DNA‐Guided Robust Single‐Protein Electronic Readout

Advanced Science, EarlyView.
Electronic measurements of single proteins can reveal fundamental insights into their structure, dynamics, and interactions, but reproducibility is severely limited by the intrinsic structural heterogeneity of proteins combined with uncontrolled molecular orientation and electrode contact geometries.
Ziyi Ju, Zhaoxiang Deng, Yueqi Li, Jinghong Li   +3 more
wiley   +1 more source

Kinetic Modeling of the Antibody Disulfide Bond Reduction Reaction With Integrated Prediction of the Drug Load Profile for Cysteine-Conjugated ADCs. [PDF]

Biotechnol Bioeng
Weggen JT, González P, Hui K, Bean R, Wendeler M, Hubbuch J.   +5 more
europepmc   +1 more source