Results 291 to 300 of about 1,312,330 (378)

Flipping the Sidedness of Disulfide Bond Formation

Journal of Molecular Biology, 2013
openaire   +4 more sources

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity. [PDF]

J Clin Invest
Liu Q, Huang J, Ding H, Tao Y, Nan J, Xiao C, Wang Y, Wu R, Ni C, Zhong Z, Zhu W, Chen J, Zhang C, He X, Xiong D, Hu X, Wang J.   +16 more
europepmc   +1 more source

Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli

, 2000
Hiroshi Kadokura, Martin W. Bader, Hongping Tian, James C.A. Bardwell, Jon Beckwith   +4 more
openalex   +1 more source

Disulfide bond formation in prokaryotes: history, diversity and design.

Biochimica et Biophysica Acta, 2014
Feras Hatahet, D. Boyd, J. Beckwith
semanticscholar   +1 more source

Real‐Time Probing of Morphological Evolution and Recrystallization During Solvent Annealing in Blade‐Coated All‐Polymer Organic Solar Cells Using In Situ X‐Ray Scattering

Advanced Science, EarlyView.
In situ grazing‐incidence X‐ray scattering and in situ UV–vis spectroscopy are being used for the first time to reveal the morphological evolution of all‐polymer solar cell (APSCs) blends during solvent vapor annealing (SVA). SVA strongly influences the recrystallization and reordering behavior of APSCs blends, successfully establishing the ...
Jialiang Hao, Yang Feng, Qianyi Ma, Hongxiang Li, Chunxia Hong, Chen Hou, Ying Wang, Yang Jing, Yiwen Li, Guangfeng Liu, Xiuhong Li, Aiguo Li, Fenggang Bian, Ruijie Ma, Yuanyang Wang, Yuying Huang, Chunming Yang   +16 more
wiley   +1 more source

MoS2 Channel‐Enhanced High‐Density Charge Trap Flash Memory and Machine Learning‐Assisted Sensing Methodologies for Memory‐Centric Computing Systems

Advanced Science, EarlyView.
Driven by AI computing demands, this study investigates MoS2 channels for 3D NAND Flash to achieve high‐density, low‐power, and reliable nonvolatile memory. MoS2 enables a large memory window and lower operating voltages with low‐k tunneling layer, demonstrating endurance of 10⁴ cycles and retention of 10⁵ s. Comprehensive analyses and machine learning‐
Ki Han Kim, Ju Han Park, Khang June Lee, Ji‐Won Seo, Yeong Kwon Kim, Junhwan Choi, Min‐Jae Seo, Byung Chul Jang   +7 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Oxidative pathways of apo, partially, and fully Zn(II)- and Cd(II)-metalated human metallothionein-3 are dominated by disulfide bond formation. [PDF]

FEBS J
Yuan AT, Stillman MJ.
europepmc   +1 more source

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules

Advanced Science, EarlyView.
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu, Xinran Liu, Mei Xue, Yushuo Xiao, Yuchen Chen, Rong Qiu, Di Wu, Yihao Zhou, Jiao Wang, Yan Yuan, Linwei Yu, Tianyi Shi, Yangkai Li, Hua Su, Hong Chen, Yong Liu, Kun Huang, Ling Zheng   +17 more
wiley   +1 more source