Results 51 to 60 of about 10,911 (198)

Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Bioassay-guided fractionation of the ethyl acetate extract from Teucrium flavum subsp. glaucum, endowed with inhibitory activity towards the HIV-1 reverse transcriptase–associated RNase H function, led to the isolation of salvigenin (1), cirsimaritin (2)
Benedetta Fois, Angela Corona, Enzo Tramontano, Simona Distinto, Elias Maccioni, Rita Meleddu, Pierluigi Caboni, Costantino Floris, Filippo Cottiglia   +8 more
doaj   +1 more source

Dereplication of Cytochalasans and Octaketides in Cytotoxic Extracts of Endophytic Fungi from Casearia arborea (Salicaceae)

Metabolites, 2022
Endophytes have been shown to be a source of novel drug prototypes. The Casearia genus is known for presenting cytotoxic clerodane diterpenes; however, there are few reports on secondary metabolites produced by its fungal microbiota. Thus, in the present
Augusto L. Santos, Marisa Ionta, Renato O. Horvath, Marisi G. Soares, Daniele O. Silva, Eunizinis S. Kawafune, Marcelo J. P. Ferreira, Patricia Sartorelli   +7 more
doaj   +1 more source

Oral Copaiba Oil‐Resin Supplementation Reduces Plasma and Hepatic Oxidative Stress in Female and Male Hypothalamic‐Obese Animals

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Oral supplementation with copaiba‐oil resin (Co‐resin) restores hepatic and plasma oxidative systems in hypothalamic‐obese male and female rats, therefore, it showed a more positive impact on females. This study highlights the therapeutic potential of Co‐resin to reduce reactive oxygen species production and restore plasma and hepatic antioxidant ...
Sirlei P. Souza, Zoé M. N. de Carvalho, Beatriz M. Daudt, Marianela A. F. Urrutia, Caroline M. Aguiar, Ellen C. Z. Gomes, Mustafa M. M. Dahleh, Marina Prigol, Gustavo P. Guerra, Lucinéia F. C. Ribeiro, Sabrina Grassiolli   +10 more
wiley   +1 more source

Discovery of VEGFR‐2 Inhibitors From Leonurus japonicus via Integrated Genetic Authentication, Molecular Networking, and In Silico Analysis

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Genetic authentication of Leonurus japonicus was confirmed using ITS sequencing. UHPLC‐MS/MS‐GNPS analysis and isolation led to a new labdane diterpenoid (1) and known compounds (2–6), with anti‐angiogenic activity validated by EPC assays and VEGFR‐2 docking studies.
Thiyagarajan Raviraj, Chen‐Lin Yu, Aekkhaluck Intharuksa, Shang‐Chih Lai, Vidya Febrasca Tenderly, Yen Chi Loo, Pin‐Wei Chen, Shih‐Wei Wang, Kartiko Arif Purnomo, Soundar Rajan Kulandhaivel, Sedin Renadi, Stephen Lirio, Yuan‐Bin Cheng, Yu‐Liang Yang, Tsong‐Long Hwang, Fang‐Rong Chang, Michal Korinek   +16 more
wiley   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Nanoencapsulation of Essential Oils: A Review of Current Trends and Advances in Preparation, Characterization, and Biomedical Applications

Nano Select, Volume 7, Issue 6, June 2026.
This review highlights nanoencapsulation as a powerful strategy to improve the stability, solubility, and bioavailability of essential oils. It surveys key EO‐producing plant families, major bioactive constituents, and therapeutic properties, alongside high‐ and low‐energy nanoformulation methods. Applications across pharmaceutical, cosmetic, food, and
Mateusz Guz, Awatif Belkhiri‐Baines, Krzysztof Szczepanowicz, Anna Trybala   +3 more
wiley   +1 more source

LC-MS-SPE-NMR for the Isolation and Characterization of neo-Clerodane Diterpenoids from Teucrium luteum subsp. flavovirens

, 2016
neo-Clerodane diterpenes of plant origin are molecules difficult to monitor due to their nonspecific UV/vis absorption. The present work describes for the first time the application of the LC-MS-SPE-NMR technique for the isolation and characterization of
Jacques Vervoort (225685), Amaya Castro (1452040), Josep Coll (5054), Sofia Moco (457289)   +3 more
core   +1 more source

Identificação de diterpenos clerodânicos em diferentes órgãos de Casearia sylvestris Swartz

Revista de Ciências Farmacêuticas Básica e Aplicada, 2010
<p align="justify">Casearia sylvestris Swartz (Salicaceae) é uma espécie vegetal arbórea ou arbustiva, disseminada pelo território brasileiro e bastante utilizada em nossa medicina popular.
Elisângela Simões de Carvalho, André Gonzaga dos Santos, Alberto José Cavalheiro   +2 more
doaj  

Linearolactone Induces Necrotic-like Death in Giardia intestinalis Trophozoites: Prediction of a Likely Target

Pharmaceuticals, 2022
Linearolactone (LL) is a neo-clerodane type diterpene that has been shown to exert giardicidal effects; however, its mechanism of action is unknown.
Raúl Argüello-García, Fernando Calzada, Bibiana Chávez-Munguía, Audifás-Salvador Matus-Meza, Elihú Bautista, Elizabeth Barbosa, Claudia Velazquez, Marta Elena Hernández-Caballero, Rosa Maria Ordoñez-Razo, José Antonio Velázquez-Domínguez   +9 more
doaj   +1 more source

Cytotoxic Clerodane Diterpenes from Casearia rupestris

, 2016
Four new clerodane diterpenes, casearupestrins A−D (1−4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6).
Nivaldo Boralle (2206480), Paulo M. P. Ferreira (2206495), Cláudia do Ó Pessoa (2206483), Luiz A. Dutra (2206477), Roseli Buzanelli Torres (2206498), Manoel O. de Moraes (562133), Letícia V. Costa Lotufo (2206489), Alberto J. Cavalheiro (2206492), Gerardo M. Vieira-Júnior (2206486), Vanderlan da S. Bolzani (2153950)   +9 more
core   +1 more source