Results 1 to 10 of about 1,611 (171)

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides [PDF]

Molecules, 2007
This paper presents a review on kaurane diterpenes and their glycoside derivatives, covering aspects of their occurrence, biological activities and the synthesis of these natural products and their analogues. First, it shows and classifies diterpenes, in
Ronan Batista
exaly   +6 more sources

Three New Ent-Kaurane Diterpenes with Antibacterial Activity from Sigesbeckia orientalis [PDF]

Molecules
Three novel ent-kaurane diterpenes, namely sigesbeckin A–C (1–3), in conjunction with eight previously identified analogues (4–11), were isolated from Sigesbeckia orientalis. Their chemical structures were resolved through multiple spectroscopic analyses.
Zhong-Shun Zhou, Zhao-Jie Wang, Bei Tian, Yan-Yan Zhu, Mei-Zhen Wei, Yun-Li Zhao, Xiao-Dong Luo   +6 more
doaj   +4 more sources

Ent-Kaurane Diterpenoids from Coffea Genus: An Update of Chemical Diversity and Biological Aspects [PDF]

Molecules
Coffee is one of the most important beverages in the world and is produced from Coffea spp. beans. Diterpenes with ent-kaurane backbones have been described in this genus, and substances such as cafestol and kahweol have been widely investigated, along ...
Víctor de C. Martins, Maria Alice E. da Silva, Valdir F. da Veiga, Henrique M. G. Pereira, Claudia M. de Rezende   +4 more
doaj   +2 more sources

Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli [PDF]

Beilstein Journal of Organic Chemistry, 2022
The clerodane and ent-kaurane diterpenoids are two typical categories of diterpenoid natural products with complicated polycyclic carbon skeletons and significant pharmacological activities. Despite exciting advances in organic chemistry, access to these
Fang-Ru Li, Xiaoxu Lin, Qian Yang, Ning-Hua Tan, Liao-Bin Dong   +4 more
doaj   +2 more sources

Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae) [PDF]

Química Nova, 2012
Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-
Dayanne Meneses Silva, Emmanoel Vilaça Costa, Paulo Cesar de Lima Nogueira, Valéria Regina de Souza Moraes, Sócrates Cabral de Holanda Cavalcanti, Marcos José Salvador, Luis Henrique Gonzaga Ribeiro, Fernanda Ramos Gadelha, Andersson Barison, Antonio Gilberto Ferreira   +9 more
doaj   +6 more sources

Cafestol-derivatives as potential FXR agonists and CYP7A1 inhibitors and their impact on hypercholesterolemia: an in silico study [PDF]

Scientific Reports
Cafestol is a hypercholesterolemic ent-kaurane diterpene found in unfiltered coffee, a regular component of the human diet. This diterpene is reported to modulate macromolecules involved in cholesterol metabolism, such as the farnesoid X receptor (FXR ...
Maria Alice Esteves da Silva, Priscila Goes Camargo, Camilo Henrique da Silva Lima, Carlos Rangel Rodrigues, Magaly Girão Albuquerque, Claudia Moraes de Rezende   +5 more
doaj   +2 more sources

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I [PDF]

Molecules, 2021
The current treatments against Leishmania parasites present high toxicity and multiple side effects, which makes the control and elimination of leishmaniasis challenging.
Chonny Herrera-Acevedo, Areli Flores-Gaspar, Luciana Scotti, Francisco Jaime Bezerra Mendonça-Junior, Marcus Tullius Scotti, Ericsson Coy-Barrera   +5 more
doaj   +3 more sources

Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase PfATP6 [PDF]

Memorias do Instituto Oswaldo Cruz, 2015
Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though
Daniel Silqueira Martins Guimarães, Amanda Luisa da Fonseca, Ronan Batista, Moacyr Comar Junior, Alaíde Braga de Oliveira, Alex Gutterres Taranto, Fernando de Pilla Varotti   +6 more
doaj   +2 more sources

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others [PDF]

Natural Products and Bioprospecting
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara.
Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu   +11 more
doaj   +2 more sources

Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells. [PDF]

ACS Omega
Gáborová M, Vágvölgyi M, Tayeb BA, Minorics R, Zupkó I, Jurček O, Béni S, Kubínová R, Balogh GT, Hunyadi A.   +9 more
europepmc   +3 more sources