Results 11 to 20 of about 1,096 (185)

Four New ent-Kaurane Diterpene Glycosides from Isodon henryi [PDF]

Molecules, 2019
To obtain diterpene glycosides from an aqueous extract of the aerial parts of Isodon henryi and further investigate their cytotoxicities, in this study, a total of seven compounds were isolated, including six ent-kaurane diterpene glycosides (1−6 ...
Ya-Lin Liu, Ling-Xia Zhang, Hong Wu, Sui-Qing Chen, Jun Li, Li-Ping Dai, Zhi-Min Wang   +6 more
doaj   +4 more sources

Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages [PDF]

British Journal of Pharmacology, 2007
Background and purpose:The kaurane diterpenes foliol and linearol are inhibitors of the activation of nuclear factor κB, a transcription factor involved in the inflammatory response. Effects of these diterpenes on apoptosis and phagocytosis have been analysed in cultured peritoneal macrophages and in the mouse macrophage cell line, RAW 264.7 ...
B, de las Heras, S, Hortelano, N, Girón, P, Bermejo, B, Rodríguez, L, Boscá   +5 more
openaire   +3 more sources

Antimicrobial Activity of Kaurane Diterpenes against Oral Pathogens

Zeitschrift für Naturforschung C, 2008
Two kaurane diterpenes, ent-kaur-16(17)-en-19-oic acid (KA) and 15-β-isovaleryloxy-entkaur- 16(17)-en-19-oic acid (KA-Ival), isolated from Aspilia foliacea, and the methyl ester derivative of KA (KA-Me) were evaluated against oral pathogens.
Sergio R, Ambrosio, Niege A J C, Furtado, Dionéia C R, de Oliveira, Fernando B, da Costa, Carlos H G, Martins, Tatiane C, de Carvalho, Thiago S, Porto, Rodrigo C S, Veneziani   +7 more
openaire   +3 more sources

13C-NMR Data of Diterpenes Isolated from Aristolochia Species [PDF]

Molecules, 2009
The genus Aristolochia,an important source of physiologically active compounds that belong to different chemical classes, is the subject of research in numerous pharmacological and chemical studies.
Antônio Flávio de Carvalho Alcântara, Patrícia Machado de Oliveira, Dorila Piló-Veloso, Alison Geraldo Pacheco   +3 more
doaj   +2 more sources

STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF DITERPENES FOR TREATMENT OF ALZHEIMER'S DISEASE [PDF]

Química Nova, 2017
Alzheimer's disease is an irreversible, degenerative and age-related disease which is growing more and more with the increase in life expectancy. Kaurane diterpenes are a class of natural products available in large amounts in nature and isolated from ...
Gabriel F. dos Santos, Rondinelle G. Pereira, Maria A. D. Boaventura, Francisco A. Macias, Gesiane da S. Lima, Amanda C. S. Coelho, Jose M. G. Molinillo, Antonio Cala, Jacqueline A. Takahashi   +8 more
doaj   +3 more sources

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity

Molecules, 2016
Aldama discolor (syn.Viguiera discolor) is an endemic Asteraceae from the Brazilian “Cerrado”, which has not previously been investigated for its chemical constituents and biological activity.
Mauro S. Nogueira, Fernando B. Da Costa, Reto Brun, Marcel Kaiser, Thomas J. Schmidt   +4 more
doaj   +2 more sources

Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase PfATP6

Memorias do Instituto Oswaldo Cruz, 2015
Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though
Daniel Silqueira Martins Guimarães, Amanda Luisa da Fonseca, Ronan Batista, Moacyr Comar Junior, Alaíde Braga de Oliveira, Alex Gutterres Taranto, Fernando de Pilla Varotti   +6 more
doaj   +2 more sources

PTP1B inhibitory activity of kaurane diterpenes isolated fromSiegesbeckia glabrescens

Journal of Enzyme Inhibition and Medicinal Chemistry, 2006
Protein tyrosine phosphatase 1B (PTP1B) is considered as a therapeutic target for the treatment of diabetes and obesity. In our preliminary screening study, a MeOH extract of the aerial part of Siegesbeckia glabrescens was found to inhibit PTP1B activity at 30 microg/mL.
Sohee, Kim, Minkyun, Na, Hyuncheol, Oh, Junpil, Jang, Cheon Bae, Sohn, Bo Yeon, Kim, Won Keun, Oh, Jong Seog, Ahn   +7 more
openaire   +3 more sources

Anti-Neuroinflammatory ent-Kaurane Diterpenoids from Pteris multifida Roots

Molecules, 2016
Activated microglia are known to be a major source of cellular neuroinflammation which causes various neurodegenerative diseases, including Alzheimer’s disease.
Jung Wha Kim, Ji Yeon Seo, Won Keun Oh, Sang Hyun Sung   +3 more
doaj   +2 more sources

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others [PDF]

Natural Products and Bioprospecting
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara.
Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu   +11 more
doaj   +2 more sources