Results 41 to 50 of about 942 (157)

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

Molecules, 2012
Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and
Jamilly Kelly Oliveira Neves, José Alexsandro da Silva, Paula Cristina Souza Barbosa, Fabiano de Sousa Vargas, Lidiam Maia Leandro, Valdir Florêncio da Veiga-Junior   +5 more
doaj   +1 more source

Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase PfATP6

Memorias do Instituto Oswaldo Cruz, 2015
Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though
Daniel Silqueira Martins Guimarães, Amanda Luisa da Fonseca, Ronan Batista, Moacyr Comar Junior, Alaíde Braga de Oliveira, Alex Gutterres Taranto, Fernando de Pilla Varotti   +6 more
doaj   +1 more source

Diversity of the diterpenes in the leaves of Xylopia laevigata (Annonaceae) and their cytotoxicities

Química Nova
The phytochemical investigation of the hexane extract which was obtained from the leaves of Xylopia laevigata (Annonaceae) produced six terpenes. Among these, five diterpenes named abieta-7,13-dien-3-one, ent-7β-acetoxy-16β-hydroxy-kaurane, 4-epi ...
Emmanoel V. Costa, Marília F. C. Sampaio, Leociley R. A. Menezes, Lívia M. Dutra, Cinara O. S. Costa, Maria Lúcia B. Pinheiro, Felipe M. A. da Silva, Milena B. P. Soares, Daniel P. Bezerra, Andersson Barison, Hector H. F. Koolen   +10 more
doaj   +1 more source

STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF DITERPENES FOR TREATMENT OF ALZHEIMER'S DISEASE

Química Nova
Alzheimer's disease is an irreversible, degenerative and age-related disease which is growing more and more with the increase in life expectancy. Kaurane diterpenes are a class of natural products available in large amounts in nature and isolated from ...
Gabriel F. dos Santos, Rondinelle G. Pereira, Maria A. D. Boaventura, Francisco A. Macias, Gesiane da S. Lima, Amanda C. S. Coelho, Jose M. G. Molinillo, Antonio Cala, Jacqueline A. Takahashi   +8 more
doaj   +1 more source

COX-2 Inhibitory Activity of Cafestol and Analogs from Coffee Beans

Natural Product Communications, 2008
Two kaurane diterpenes, namely cafestol ( 1 ) and kahweol ( 2 ), were isolated from hydrolyzed fraction of the fixed oil of Ethiopian Coffea arabica unroasted beans, using AgNO 3 -impregnated silica gel chromatography. In addition, cafestol palmitate ( 3
Ilias Muhammad, Satoshi Takamatsu, Jamal Mustafa, Shabana I. Khan, Ikhlas A. Khan, Volodymyr Samoylenko, Jaber S. Mossa, Farouk S. El-Feraly, D. Chuck Dunbar   +8 more
doaj   +1 more source

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity

Molecules, 2016
Aldama discolor (syn.Viguiera discolor) is an endemic Asteraceae from the Brazilian “Cerrado”, which has not previously been investigated for its chemical constituents and biological activity.
Mauro S. Nogueira, Fernando B. Da Costa, Reto Brun, Marcel Kaiser, Thomas J. Schmidt   +4 more
doaj   +1 more source

Kaurane-Type Diterpenes from Fern Frond Exudates

Zeitschrift für Naturforschung C, 1989
Abstract The viscid exudate found on fronds of the fern, Cheilanthes kaulfussii, consists of terpenoids in which flavonoid aglycones are dissolved. One of the terpenes is shown to be em-kaur-16-en-19-oic acid. The farinose frond exudate of Notholaena pallens contains this acid as the major constituent and its 3 R-hydroxy derivative ...
Peter Rüedi, Eckhard Wollenweber, Dieter Marx, Cornelia Scheele   +3 more
openaire   +1 more source

Orthoquinone, Cyclic, and Acyclic α‐Diketone Natural Products: From Food Applications to Pharmacotherapy

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain, Daijie Wang, Satyajit D. Sarker, Lutfun Nahar, Nilufar Z. Mamadalieva, Jianbo Xiao   +5 more
wiley   +1 more source

SYNTHETIC TRANSFORMATIONS OF ENT-KAURENOIC ACID [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2015
This paper presents a review on kaurane diterpenes, covering various aspects of chemical and microbiological transformations of native ent-kaurenoic acid, namely, its reactions via COOH groups, double bonds and rearrangements of the carbon skeleton that ...
Olga Morarescu
doaj  

A Diterpene, Ent‐9α,11α‐dihydroxy‐15‐oxo‐kaur‐16‐En‐19‐oic Acid From the Herbal Plant Adenostemma lavenia, Induces Apoptosis and Autophagy in Oral Squamous Cell Carcinoma Cells

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Oral squamous cell carcinoma (OSCC) is one of the leading causes of cancer‐related mortality in Taiwan. Natural products have long served as a valuable source of chemotherapeutic agents. In the present study, we investigated the antitumor effects of DOK, a diterpene derived from Adenostemma lavenia, a plant traditionally used an herbal tea, in OSCC ...
Kun-Chang Wu, Li-Yuan Bai, Po-Chen Chu, Jing-Lan Hu, Jing-Ru Weng, Anupama Bose   +5 more
wiley   +1 more source