Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products. [PDF]
FEBS JWe have converted the only known true bacterial monoterpene synthase, cineole synthase from Streptomyces clavuligerus (bCinS, C10 substrate), to a highly competent sesquiterpene synthase (C15) with a minimum number of rational mutations. By comparison with diterpene synthases (C20), we were then able to bestow diterpene synthase activity on bCinS. This
Leferink NGH +3 more
europepmc +2 more sources
Effect of processing on the alkaloids in Aconitum tubers by HPLC-TOF/MS
Journal of Pharmaceutical Analysis, 2017 According to the Chinese Pharmacopoeia 2015, only processed Aconitum tubers can be clinically applied, and the effect of processing is unclear. This research aimed to explore the effect of processing on cardiac efficacy of alkaloids in Aconitum tubers ...
Min Liu +6 more
doaj +1 more source
Molecules, 2022 In an effort to explore bioactive anti-inflammatory compounds from natural Actinobacteria resources from all over Taiwan and various ecological environments, an active strain of Acrocarpospora punica was collected at Taitung County in Taiwan, prepared ...
Ming-Der Wu, Ming-Jen Cheng
doaj +1 more source
Research Progress and NMR Spectral Features of Natural C19-Diterpenoid Alkaloids
Chinese Journal of Magnetic Resonance, 2019 Majority of diterpenoid alkaloids are C19-diterpenoid alkaloids found in the plants from the genera Aconitum, Delphinium and Consolida (Ranunculaceae). C19-diterpenoid alkaloids have attached lots of research interests due to their complex structures and
YIN Tian-peng +3 more
doaj +1 more source
Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare. [PDF]
, 2019 BackgroundHorehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes.
Addison, J Bennett +5 more
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Jasmonate-induced defense mechanisms in the belowground antagonistic interaction between Pythium arrhenomanes and Meloidogyne graminicola in rice [PDF]
, 2019 Next to their essential roles in plant growth and development, phytohormones play a central role in plant immunity against pathogens. In this study we studied the previously reported antagonism between the plant-pathogenic oomycete Pythium arrhenomanes ...
Alam, Md. Zahangir +11 more
core +1 more source
Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence
Toxins, 2023 Labdane-related diterpenoids, momilactones A and B were isolated and identified in rice husks in 1973 and later found in rice leaves, straws, roots, root exudate, other several Poaceae species and the moss species Calohypnum plumiforme.
Hisashi Kato-Noguchi
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Phytochemical Assessment on N-hexane Extract and Fractions of Marsilea Crenata Presl. Leaves Through Gc-ms [PDF]
, 2016 Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogen emerged as a potential alternative of estrogen with minimum side effects.
Ma'arif, B. (Burhan) +2 more
core +4 more sources
Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao
Molecules, 2016 Isodon rubescens has been used as a traditional green tea for more than 1000 years and many medicinal functions of I. rubescens are also very useful, such as its well-known antitumor and antibacterial activities.
Dahong Li +9 more
doaj +1 more source
An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae [PDF]
, 2017 Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide.
Azevedo, Vasco A.C. +13 more
core +6 more sources