Divergent Total Synthesis of Denudatine Alkaloids Cochlearenine, Macrocentrine, Dictizine, 15-Veratroyl-17-Acetyl-19-Oxodictizine, and the Proposed Structure of Acochlearine. [PDF]
Angew Chem Int Ed EnglAn intramolecular Mannich reaction (A/B/E/F rings) and intermolecular Diels–Alder reactions (C/D rings) afforded a cage‐like hexacyclic core skeleton of denudatine alkaloids. Derivatization of the hexacyclic intermediate enabled the first asymmetric total syntheses of four denudatine alkaloids: (–)‐cochlearenine, (–)‐macrocentrine, (–)‐dictizine, and (–
Kawano S +5 more
europepmc +3 more sources
Network-analysis-guided synthesis of weisaconitine D and liljestrandinine. [PDF]
, 2015 General strategies for the chemical synthesis of organic compounds, especially of architecturally complex natural products, are not easily identified. Here we present a method to establish a strategy for such syntheses, which uses network analysis.
Gallego, GM +8 more
core +4 more sources
Enantioselective Total Synthesis of Macfarlandin C, a Spongian Diterpenoid Harboring a Concave-Substituted cis-Dioxabicyclo[3.3.0]octanone Fragment. [PDF]
, 2020 The enantioselective total synthesis of the rearranged spongian diterpenoid (-)-macfarlandin C is reported. This is the first synthesis of a rearranged spongian diterpenoid in which the bulky hydrocarbon fragment is joined via a quaternary carbon to the ...
Allred, Tyler K +4 more
core +2 more sources
Research Progress and NMR Spectral Features of Natural C19-Diterpenoid Alkaloids
Chinese Journal of Magnetic Resonance, 2019 Majority of diterpenoid alkaloids are C19-diterpenoid alkaloids found in the plants from the genera Aconitum, Delphinium and Consolida (Ranunculaceae). C19-diterpenoid alkaloids have attached lots of research interests due to their complex structures and
YIN Tian-peng +3 more
doaj +1 more source
Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare. [PDF]
, 2019 BackgroundHorehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes.
Addison, J Bennett +5 more
core +6 more sources
Jasmonate-induced defense mechanisms in the belowground antagonistic interaction between Pythium arrhenomanes and Meloidogyne graminicola in rice [PDF]
, 2019 Next to their essential roles in plant growth and development, phytohormones play a central role in plant immunity against pathogens. In this study we studied the previously reported antagonism between the plant-pathogenic oomycete Pythium arrhenomanes ...
Alam, Md. Zahangir +11 more
core +1 more source
Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence
Toxins, 2023 Labdane-related diterpenoids, momilactones A and B were isolated and identified in rice husks in 1973 and later found in rice leaves, straws, roots, root exudate, other several Poaceae species and the moss species Calohypnum plumiforme.
Hisashi Kato-Noguchi
doaj +1 more source
Phytochemical Assessment on N-hexane Extract and Fractions of Marsilea Crenata Presl. Leaves Through Gc-ms [PDF]
, 2016 Estrogen deficiency causes various health problems in postmenopausal women, including osteoporosis. Phytoestrogen emerged as a potential alternative of estrogen with minimum side effects.
Ma'arif, B. (Burhan) +2 more
core +4 more sources
Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao
Molecules, 2016 Isodon rubescens has been used as a traditional green tea for more than 1000 years and many medicinal functions of I. rubescens are also very useful, such as its well-known antitumor and antibacterial activities.
Dahong Li +9 more
doaj +1 more source
An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae [PDF]
, 2017 Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide.
Azevedo, Vasco A.C. +13 more
core +6 more sources