Results 161 to 170 of about 270,943 (291)

Detection of a Distinct Erythropoietin (EPO) Profile After Isoelectric Focusing in Patients With Familial Erythrocytosis

Drug Testing and Analysis, EarlyView.
A basic EPO IEF profile was identified in patients with familial erythropoiesis linked to mutations in noncoding parts of EPO gene. Comparison of blood and urine EPO profiles from these patients differed from adult wild‐type EPO (WT) and from Eprex‐administered patients. Patients' EPO do not differ from WT EPO after analysis using SDS‐PAGE/SAR‐PAGE. It
Laurent Martin, Salam Idriss, Nada Maaziz, Soizic Huerre, Lamine Redouane Mekacher, Kahina Lahmek, François Girodon, Betty Gardie, Magnus Ericsson, Alexandre Marchand   +9 more
wiley   +1 more source

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, EarlyView.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source

Intrinsically disordered regions in the yeast transcriptional regulator Ixr1 support prion-like behavior. [PDF]

Sci Rep
Barreiro-Alonso A, Rey-Souto C, Lamas-Maceiras M, Pérez-Martínez JM, Franco-Gacio A, Rodríguez-Belmonte E, Cerdán ME, Vizoso-Vázquez Á.   +7 more
europepmc   +1 more source

Inaktivierung von Stickstoffmonoxid durch Dithiothreitol

, 2009
Bernd Kolesnik Graz, Univ., Dipl.-Arb ...
openaire  

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Modification‐Response Integrated Modules Driven Cyclization‐Dependent Prodrug Self‐Assembly for Reshaping Pro‐Apoptotic Tumor Redox Homeostasis

Exploration, EarlyView.
1. The concept of modification‐response integrated modules was proposed for the first time. 2. Simple, efficient, and feasible drug delivery platforms were developed for systematic regulation of tumor redox microenvironment and reshaping of pro‐apoptotic tumor redox homeostasis.
Yixin Sun, Shiyi Zuo, Wenfeng Zang, Lingxiao Li, Xianbao Shi, Mingzhong Li, Zhonggui He, Bingjun Sun, Jin Sun   +8 more
wiley   +1 more source

Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis

Interdisciplinary Medicine, EarlyView.
Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis. Abstract Interstitial fibrosis is the best indicator of irreversible or ongoing renal injury after kidney transplantation and faces considerable diagnostic challenges.
Wenxuan Zhao, Yang Xu, Yuewen Wang, Shihao Jin, Wenhui Wang, Zeming Yu, Yanwen Zhang, Yuxin Zhang, Deling Kong, Bing Wang, Zhenzhou Wu, Jie Zhao, Yuebing Wang   +12 more
wiley   +1 more source

Rare case of warm IgM autoimmune hemolytic anemia. [PDF]

Transfusion
Tordon B, Alhomsi N, Iqbal A, Gangji A, Clarke G, Ning S.   +5 more
europepmc   +1 more source

Capture of adeno‐associated viruses from clarified lysate by continuous flow ultracentrifugation: a comparative study of iodixanol and sucrose gradients

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Adeno‐Associated Virus vectors are widely used in gene therapy due to their safety and efficacy. Despite the interest in their therapeutical application, AAV purification remains a significant challenge. Density gradient ultracentrifugation using cesium chloride, sucrose, or iodixanol gradients are common methods for AAV ...
Sabrina Leigheb, Maral Rahimzadeh, Nikolaus Virgolini, Aida Tleuova, Mahbod Mousavian, Astrid Dürauer, Patricia Pereira Aguilar   +6 more
wiley   +1 more source

Erratum: A simple goniometer-compatible flow cell for serial synchrotron X-ray crystallography. Corrigendum. [PDF]

J Appl Crystallogr
Ghosh S, Zorić D, Dahl P, Bjelčić M, Johannesson J, Sandelin E, Borjesson P, Björling A, Banacore A, Edlund P, Aurelius O, Milas M, Nan J, Shilova A, Gonzalez A, Mueller U, Brändén G, Neutze R.   +17 more
europepmc   +1 more source