Results 81 to 90 of about 36,307 (147)

The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Sodium‐glucose cotransporter 2 (SGLT2) inhibitors have been shown to improve renal and cardiovascular outcomes in patients with type 2 diabetes. Limited evidence exists about the efficacy and safety of SGLT2 inhibitors in patients with frailty. Methods This was a post hoc pooled, participant‐level data analysis of the CANVAS Program
Tu N. Nguyen, Jie Yu, Vlado Perkovic, Meg Jardine, Kenneth W. Mahaffey, Clara K. Chow, Clare Arnott, Richard I. Lindley   +7 more
wiley   +1 more source

The Impact of Vatinoxan on the Concentrations of Medetomidine, Midazolam, and Fentanyl in Central Nervous System After Subcutaneous Co‐Administration in Rats

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Our aim was to investigate whether vatinoxan, a peripherally acting alpha2‐adrenoceptor antagonist, would affect the concentrations of medetomidine, midazolam, and fentanyl in the central nervous system after subcutaneous co‐administration. Twelve healthy male Wistar rats, aged between 13 and 15 weeks, were used in this study.
Juhana Honkavaara, Emily Lindh, Anna Meller, Karoliina Alm, Marja R. Raekallio, Pernilla Syrjä   +5 more
wiley   +1 more source

Hypophosphatemia in Intensive Care Unit Canine Patients: Occurrence and Association With Mortality and Duration of Hospitalization

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Hypophosphatemia is commonly observed in unselected human intensive care unit (ICU) patients, and it has been associated, although inconsistently, with worse outcomes and longer duration of hospitalization (DOH). The incidence of hypophosphatemia and its association with mortality and DOH in ICU canine patients is unknown ...
Ioannis L. Oikonomidis, Paul Rees, Jorge Hernando Sanz, Glynn Woods   +3 more
wiley   +1 more source

How much furosemide should be administered to prevent transfusion‐associated circulatory overload? Results of a dose‐finding study

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Transfusion‐associated circulatory overload (TACO) is a common and life‐threatening transfusion complication. Because of uncertainty regarding dosing, pre‐transfusion furosemide prophylaxis is not widely endorsed. The aim of this study was to generate a furosemide dose–response curve in TACO‐susceptible patients using
Lianne Rotin, Liying Zhang, Chantal Armali, Amie Malkin, Sophia Massin, Harley Meirovich, Daniel Roque, Samia Saeed, Shangari Vijenthira, Yulia Lin, Jacob Pendergrast   +10 more
wiley   +1 more source

Water diuresis [PDF]

The Journal of Physiology, 1930
openaire   +2 more sources

Plasticity of the heart in response to changes in physical activity

The Journal of Physiology, EarlyView.
Abstract figure legend The heart adapts to changes in physical activity, with inactivity (e.g. bed rest or spaceflight) causing cardiac atrophy and ventricular stiffening, and endurance exercise training leading to eccentric hypertrophy and improved ventricular compliance.
Eric T. Hedge, Tiffany L. Brazile, Richard L. Hughson, Benjamin D. Levine   +3 more
wiley   +1 more source

Physiologic responses to water immersion in man: A compendium of research [PDF]

A total of 221 reports published through December 1973 in the area of physiologic responses to water immersion in man were summarized. The author's abstract or summary was used whenever possible.
Dorchak, K. J., Greenleaf, J. E., Kollias, J., Vanderveer, D.   +3 more
core   +1 more source

Regulation of atrial natriuretic factor release in man: Effect of water immersion [PDF]

, 1986
Arendt, Rainer M., Gerbes, Alexander L., Jüngst, Dieter, Paumgartner, Gustav, Schnizer, W., Silz, S., Zähringer, J.   +6 more
core   +1 more source

Incidence of atrial fibrillation in patients with an insertable cardiac monitor and symptomatic heart failure

ESC Heart Failure, Volume 12, Issue 3, Page 1693-1702, June 2025.
Atrial fibrillation (AF) was observed in almost half of patients with insertable cardiac monitor and symptomatic heart failure (HF). One‐fourth of the patients had new onset AF and a higher rate of HF events compared with patients without AF. AF incidence was similar in HF patients with preserved versus reduced left ventricular ejection fraction ...
Muhammad Shahzeb Khan, Michael R. Zile, Rami Kahwash, Shantanu Sarkar, Brian Van Dorn, Jodi Koehler, Noreli Franco, Bart Gerritse, Javed Butler   +8 more
wiley   +1 more source

The ADESTE trial: A phase 2 study of enibarcimab, a monoclonal antibody targeting adrenomedullin, in acute heart failure

ESC Heart Failure, Volume 12, Issue 3, Page 1848-1860, June 2025.
Abstract Aims This study aimed to conduct a phase 2 proof‐of‐concept and safety study to evaluate the effect of ENIBARCIMAB (EN), a non‐neutralizing humanized monoclonal antibody targeting the N‐terminus of adrenomedullin (ADM), administered immediately after stabilization with standard of care (SoC) treatment, in patients hospitalized for acute heart ...
Anggoro Budi Hartopo, Arinal Chairul Achyar, Hendry Purnasidha Bagaswoto, Firandi Saputra, Hasanah Mumpuni, Dyah Adhi Kusumastuti, Teguh Triyono, Usi Sukorini, Metalia Puspitasari, Budi Yuli Setianto, Mohammad Saifur Rohman, Muhammad Anshory, Yoga Waranugraha, Putri Annisa Kamila, Agustin Iskandar, Hani Susianti, Andreas Bergman, Claudia Knothe, Paola Antonini, Salvatore Di Somma   +19 more
wiley   +1 more source