Results 71 to 80 of about 5,417,325 (244)

A Pilot Randomized Study of NAT2 and YEATS4 Pharmacogenetic Return of Results in Adults with Hypertension and African Ancestry: The GUARDD‐US PGx Study

Clinical Pharmacology &Therapeutics, EarlyView.
Almost half of individuals with hypertension fail to achieve recommended blood pressure (BP) goals. Pharmacogenetic gene‐drug interactions may alter the efficacy of antihypertensive agents. We conducted a multicenter randomized controlled sub‐study of participants (N = 1874) with hypertension and self‐reported African ancestry to determine whether ...
Philip E. Empey, Nita A. Limdi, Dinushika Mohottige, Kady‐Ann Steen‐Burrell, Hrishikesh Chakraborty, Khoa A. Nguyen, Alexander S. Parker, Emily J. Cicali, Girish N. Nadkarni, Michelle A. Ramos, Sabrina Clermont, Erica N. Elwood, Mimsie Robinson, Nandini Shroff, Marc B. Rosenman, Ronald Huang, Larisa H. Cavallari, Julie A. Johnson, Paul R. Dexter, Todd C. Skaar, Kerri L. Cavanaugh, Christina M. Wyatt, Carol R. Horowitz, Rhonda M. Cooper‐DeHoff, Michael T. Eadon, on behalf of the IGNITE Pragmatic Trials Network   +25 more
wiley   +1 more source

DIAGNOSTIC USEFULNESS OF THE RANDOM URINE NA/K RATIO IN PREDICTING THERAPEUTIC RESPONSE FOR DIURETICS IN CIRRHOTIC PATIENTS WITH ASCITES [PDF]

Journal of the Egyptian Society of Parasitology, 2013
Ascites is a major complication of liver cirrhosis which carries a poor prognosis. Diuretics are used in treatment of ascites in addition to salt restriction. Monitoring of diuretic response can be achieved by measurement of 24 hours urinary sodium. This
MOHAMED KHEDR, MOHAMED SALAH, ISMAIL EL MANSY, EL SAYED MOHII   +3 more
doaj   +1 more source

Potential Contamination Cases in Anti‐Doping: Experiences and Practices of 33 Anti‐Doping Organisations

Drug Testing and Analysis, EarlyView.
Across 33 Anti‐Doping Organisations (ADOs), 85% reported experiencing at least one contamination‐claim case in 2024–2025, but only 36% operate a standardised process for handling such claims. Dietary supplements were the leading alleged contamination source (76% of ADOs), followed by food (42%) and pharmaceutical products, intimate contact, and other ...
Kristian Slíž, Liene Kozlovska, Fredrik Lauritzen   +2 more
wiley   +1 more source

Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure [PDF]

, 2017
Background: Loop diuretic resistance is a common barrier to effective decongestion in acute heart failure (AHF), and is associated with poor outcome. Specific mechanisms underlying diuretic resistance are currently unknown in contemporary AHF patients ...
ter Maaten, Jozine M., Wilson, F. Perry, Tang, W. H. Wilson, Bellumkonda, Lavanya, D'Ambrosi, Julie, Hanberg, Jennifer S., Rao, Veena S., Damman, Kevin, Broughton, J. Sam, Damman, Kevin; id_orcid, Voors, Adriaan A., Testani, Jeffrey M., Assefa, Mahlet, Ellison, David H.   +13 more
core   +1 more source

Emotion Regulation in Response to Stress in the Daily Lives of Women With and Without Eating Disorders: An Ecological Momentary Assessment Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Emotion regulation difficulties are known risk/maintenance factors for eating disorders (EDs). Few studies have investigated use of adaptive/maladaptive emotion regulation strategies in people with EDs, especially using ecologically valid data.
Sarah E. Racine, Ege Bicaker, Alexia E. Miller, Vittoria Trolio, Lisa Y. Zhu   +4 more
wiley   +1 more source

Association between VExUS score and worsening renal function during diuretic therapy in the ICU

Intensive Care Medicine Experimental
Background In intensive care unit (ICU) settings, venous excess ultrasound (VExUS) score has gained attention for predicting Acute Kidney Injury (AKI).
Corentin Evezard, Pierre Alain Bahr, Maxime Nguyen, Belaid Bouhemad, Pierre-Gregoire Guinot   +4 more
doaj   +1 more source

Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3):protocol for a randomised double-blind trial in patients with essential hypertension [PDF]

, 2015
INTRODUCTION: Thiazide diuretics are associated with increased risk of diabetes mellitus. This risk may arise from K(+)-depletion. We hypothesised that a K(+)-sparing diuretic will improve glucose tolerance, and that combination of low-dose thiazide with
Salsbury, J, Williams, B, Caulfield, M, Williams, Bryan, MacDonald, TM, Cruickshank, JK, MacDonald, Thomas M., McInnes, Gordon, Salsbury, Jackie, Morant, Steve, Ford, I, Morant, S, Sever, Peter, Caulfield, Mark, Brown, MJ, Ford, Ian, McInnes, G, Webb, DJ, Brown, Morris J., Cruickshank, J. Kennedy, Webb, David J., Sever, P   +21 more
core   +2 more sources

Beyond BMI: Unsupervised Machine Learning Clustering of Bioelectrical Impedance Phenotypes Is Associated With Weight‐Recovery Trajectories in Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To identify data‐driven body composition phenotypes in patients with moderate‐to‐extreme anorexia nervosa (AN) using machine learning (ML) clustering of bioelectrical impedance analysis (BIA) parameters, and to test whether these phenotypes have specific psychopathological and childhood trauma profiles while correlating with early ...
Emanuele Cassioli, Gaia Maiolini, Eleonora D'Areglia, Livio Tarchi, Eleonora Rossi, Veronica Ceccarelli, Cristiano Dani, Luca Zompa, Chiara Ranieri, Enrico Lodovici, Anita Nannoni, Valdo Ricca, Giovanni Castellini   +12 more
wiley   +1 more source

Urinary Excretion Profile of Torasemide and its Diuretic Action in Dogs

, 1996
The plasma concentration profile, urinary excretion rate and diuretic response were studied in anaesthetized dogs after an intravenous administration of torasemide or furosemide.
Yoshihisa Sogame, Yoshio Tsuda, Kanemichi Okano, Kazutaka Hayashi, Takeshi Uchida   +4 more
core   +1 more source

Sensitivity and Criterion Validity of ED100K Lifetime Eating Disorder Diagnoses: A Study Using a National Eating Disorder Quality Register

International Journal of Eating Disorders, EarlyView.
ABSTRACT Background Epidemiological and genomic studies of eating disorders (ED) require scalable approaches to case ascertainment. The self‐report ED100K questionnaire assesses lifetime ED diagnoses, has been translated into several languages, and has been used in large cohort studies, with data shared or planned for sharing through major repositories
Hunna J. Watson, Andreas Birgegård, Liv Hog, Lisa Dinkler, Emma Forsén Mantilla, Laura M. Thornton, Cynthia M. Bulik   +6 more
wiley   +1 more source