Results 41 to 50 of about 132,183 (303)

A prospective study of the effect of antihypertensive medications on the sexual functions of hypertensive adult male patients

Future Science OA, 2020
Background: The potential for antihypertensive medications to produce deleterious adverse effects on sexual functions among hypertensive adult male patients has been widely reported, such adverse effects may limit drug adherence and compliance.
Akinwumi Akinyinka Akinyede, Obiyo Nwaiwu, Olumuyiwa John Fasipe, Adedunni Olusanya, Sunday Olufemi Olayemi, Bisola Akande   +5 more
doaj   +1 more source

Microvascular damage is associated with carotid wall structural changes in Systemic Sclerosis: a capillaroscopy and ultrasound‐based observational study

Arthritis Care &Research, Accepted Article.
Introduction Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

The Effect of Early Diuretic Treatment on Clinical Outcomes in Patients with Acute Heart Failure: Door to Diuretic

Bagcilar Medical Bulletin, 2023
Objective:It was aimed to investigate the effect of early diuretic treatment on hospitalization and short-term mortality in patients with acute heart failure.Method:Our study was carried out as a retrospective, single-centered, observational study in the
Abuzer Özkan, Kadir Özsivri, Abdullah Algın, İbrahim Altunok, Serdar Özdemir, Abuzer Coşkun   +5 more
doaj   +1 more source

Rational pharmacotherapy of arterial hypertension in real clinical practice: diuretics through drug safety

, 2023
The use of diuretics in arterial hypertension is pathogenetically justified, which is due to the significant role of an increase in the volume of circulating blood and the retention of sodium ions in the internal environment of the body, in increasing ...
Dmitry I. Trukhan, Natalya V. Bagisheva
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Diuretics — a review of the current knowledge

, 2023
Diuretics are drugs that increase diuresis and natriuresis. Diuretics reduce sodium reabsorption in the proximal tubule (SGLT2 inhibitors, carbonic anhydrase inhibitors), the loop of Henle (loop diuretics), the distal tubule (thiazide and thiazide-like ...
Więcek, Andrzej; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Surma, Stanisław; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Adamczak, Marcin; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice   +2 more
core   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter

Nature Communications
Thiazide-type and thiazide-like diuretics are structurally distinct first-line antihypertensive drugs that target the sodium-chloride cotransporter (NCC) in the kidney.
Chien-Ling Lee, Jianxiu Zhang, Liang Feng   +2 more
doaj   +1 more source

Impact of Acute Functional Decline on Frailty and Mortality in Acutely Hospitalized Older Persons

AGING MEDICINE, EarlyView.
Older persons with acute functional decline are often severely frail. Male sex, cognitive impairment, diabetes mellitus type 2, cancer, hearing impairment, and nursing home living increase the risk of severe frailty or death and should be considered when person‐centered care is planned for hospitalized older people.
Ali Vahedi, Maria Eriksdotter, Hege Ihle‐Hansen, Torgeir Bruun Wyller, Anne Rita Øksengård, Brynjar Fure   +5 more
wiley   +1 more source