Results 1 to 10 of about 633,245 (221)

Loop Diuretics

Kidney and Blood Pressure Research, 1987
Loop diuretics such as furosemide, piretanide, and bumetanide bind reversibly to the Na⁺2Cl^-K+ carrier. This transporter is responsible for the uptake of Cl^- into the thick ascending limb segment.
R, Greger, P, Wangemann
openaire   +2 more sources

Pharmacogenetics of loop diuretics

Clinical Pharmacology & Therapeutics, 2004
Objective Genetic variability in pharmacokinetics and pharmacodynamics of diuretics is incompletely studied. We compared the extent of variability in different loop diuretics and determined to what extent this is influenced by polymorphisms in candidate genes. Methods Single oral doses of bumetanide 2 mg, furosemide 80 mg and torasemide 10
Vormfelde, Stefan Viktor, Zirk, A., Westermann, J., Torn, M., Tuchen, F., Toliat, Mohammad Reza, Brockmoeller, Juergen   +6 more
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Loop Diuretics in Clinical Practice [PDF]

Electrolytes & Blood Pressure, 2015
Diuretics are commonly used to control edema across various clinical fields. Diuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased urinary sodium and water excretion. Loop diuretics are the most potent diuretics. In this article, we review five important aspects of loop diuretics, in particular furosemide, which must ...
Oh, Se Won, Han, Sang Youb
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Vascular effects of loop diuretics [PDF]

Cardiovascular Research, 1996
Although it is generally believed that the beneficial effect of loop diuretics is the result of a rapid increase in diuresis, substantial evidence, from a large number of in vitro and in vivo experiments, has accumulated showing that administration of furosemide causes direct vascular effects, which probably contribute to its acute clinical effects ...
Dormans, T.P.J., Pickkers, P., Russel, F.G.M., Smits, P.   +3 more
openaire   +4 more sources

The genetics of loop diuretic effects [PDF]

The Pharmacogenomics Journal, 2010
Little is known about the genetic impact on loop diuretic effects. We newly investigated five genetic polymorphisms in 95 healthy volunteers, who had ingested bumetanide, frusemide and torsemide. The subjects excreted means of 20.2 g sodium chloride, 2.87 g potassium and 261 mg calcium over 24 h.
Vormfelde, Stefan Viktor, Brockmoeller, Juergen   +1 more
openaire   +3 more sources

Loop Diuretics

, 2012
James W. Davis, Dana Forman, La Scienya M. Jackson, James W. Davis, Javier Garau, David N. O’Dwyer, Elisa Vedes, Gihan Abuella, Maurizio Cecconi, Howard A. Greller, Michelle K. McNutt, Rosemary A. Kozar, Jorge Cerdá, Andrew Davenport, Abhay Dhand, Gary P. Wormser   +15 more
europepmc   +2 more sources

Loop Diuretic Absorption [PDF]

Congestive Heart Failure, 2000
Objectives. The present study was undertaken to determine if direct blockade of angiotensin II receptors by losartan potassium as compared to ACE inhibition might result in greater tolerability in patients with congestive heart failure in whom ACE inhibition resulted in hyperkalemia and azotemia.Background.
James Blake, Richard B. Devereux
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Thiazide and Loop Diuretics

The Journal of Clinical Hypertension, 2011
KEY POINTS AND PRACTICAL RECOMMENDATIONS: •  Although chlorthalidone and hydrochlorothiazide are structurally similar, they are very different pharmacokinetically, with chlorthalidone having both an extremely long half-life (approximately 40 to 60 hours) and a large volume of distribution, with gradual elimination from the plasma compartment by tubular
Domenic A, Sica, Barry, Carter, William, Cushman, Lee, Hamm   +3 more
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Novel Intranasal Loop Diuretic

JACC: Basic to Translational Science, 2023
Benjamin Esque, Eric D. Adler, Daniel Bensimhon   +2 more
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Loop diuretics association with Alzheimer's disease risk. [PDF]

Front Aging, 2023
Graber-Naidich A, Lee J, Younes K, Greicius MD, Le Guen Y, He Z.   +5 more
europepmc   +1 more source